Technology Process of C18H21ClFN3O2
There total 9 articles about C18H21ClFN3O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: potassium carbonate / dichloromethane; water / 20 °C
2: sodium hydride / N,N-dimethyl-formamide / 20 °C
3: trifluoroacetic acid / 20 °C
4: potassium iodide; potassium carbonate / acetonitrile / 18 h / 55 °C
5: toluene / 15.25 h / -78 - 55 °C
6: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 20 °C
7: boron tribromide / dichloromethane / -78 °C
8: triethylamine / dichloromethane / 20 °C
9: potassium fluoride / dimethyl sulfoxide / 90 °C
With
potassium fluoride; sodium hexamethyldisilazane; boron tribromide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2013.02.009
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium hydride / N,N-dimethyl-formamide / 20 °C
2: trifluoroacetic acid / 20 °C
3: potassium iodide; potassium carbonate / acetonitrile / 18 h / 55 °C
4: toluene / 15.25 h / -78 - 55 °C
5: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 20 °C
6: boron tribromide / dichloromethane / -78 °C
7: triethylamine / dichloromethane / 20 °C
8: potassium fluoride / dimethyl sulfoxide / 90 °C
With
potassium fluoride; sodium hexamethyldisilazane; boron tribromide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2013.02.009