(R)-4-(3-{4-[3-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-phenoxy}-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(R)-4-(3-{4-[3-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-phenoxy}-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
CAS No.:136057-23-3
Molecular Formula:C₃₅H₄₀N₂O₇
Molecular Weight:600.712
Hs Code.:

(R)-4-(3-{4-[3-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-phenoxy}-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Chemical Property of (R)-4-(3-{4-[3-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-phenoxy}-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of (R)-4-(3-{4-[3-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-phenoxy}-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 12 articles about (R)-4-(3-{4-[3-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-phenoxy}-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3650-78-0,84878-00-2,71205-17-9
methyl (E)-4-bromocinnamate

: 136057-23-3
(R)-4-(3-{4-[3-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-phenoxy}-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

2: 91 percent / H₂ / 10percent Pd/C / methanol / 16 h

3: 100 percent / LiOH / tetrahydrofuran / 17 h / Ambient temperature

4: Et₃N / diethyl ether / 2 h / 0 °C

5: 1) BuLi / 1) THF, hexane, -78 deg C, 10 min, 2) THF, hexane, diethylether, RT, 1 h

With lithium hydroxide; n-butyllithium; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;

Reference yield:

: 1200-07-3,5676-63-1,17916-60-8
trans-4-bromocinnamic acid

: 136057-23-3
(R)-4-(3-{4-[3-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-phenoxy}-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / SOCl₂ / 3 h / Heating

3: 91 percent / H₂ / 10percent Pd/C / methanol / 16 h

4: 100 percent / LiOH / tetrahydrofuran / 17 h / Ambient temperature

5: Et₃N / diethyl ether / 2 h / 0 °C

6: 1) BuLi / 1) THF, hexane, -78 deg C, 10 min, 2) THF, hexane, diethylether, RT, 1 h

With lithium hydroxide; n-butyllithium; thionyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 136057-23-3
(R)-4-(3-{4-[3-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-propyl]-phenoxy}-phenyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / NaOH / 2-methyl-propan-2-ol / 17 h / Ambient temperature

2: 89 percent / LiBH₄ / diethyl ether / 7 h / 0 °C

3: 91 percent / toluene-p-sulphonic acid / CH₂Cl₂ / 1 h / Ambient temperature

5: 91 percent / H₂ / 10percent Pd/C / methanol / 16 h

6: 100 percent / LiOH / tetrahydrofuran / 17 h / Ambient temperature

7: Et₃N / diethyl ether / 2 h / 0 °C

8: 1) BuLi / 1) THF, hexane, -78 deg C, 10 min, 2) THF, hexane, diethylether, RT, 1 h

With lithium hydroxide; sodium hydroxide; lithium borohydride; n-butyllithium; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; tert-butyl alcohol;