C₃₈H₅₃NO₅Si

Base Information

• Chemical Name: C₃₈H₅₃NO₅Si
• CAS No.: 105880-47-5
• Molecular Formula: C₃₈H₅₃NO₅Si
• Molecular Weight: 631.928
• Mol file: 105880-47-5.mol

Synonyms:

Chemical Property of C₃₈H₅₃NO₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₅₃NO₅Si

There total 11 articles about C₃₈H₅₃NO₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.3%

(R)-1-(1-naphthyl)ethyl isocyanate (42340-98-7) + C25H42O4Si (105880-45-3) → C38H53NO5Si (105880-46-4) + C38H53NO5Si (105880-47-5)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; at 45 ℃; for 8h;

DOI:10.1021/jo00389a038

Reference yield:

1-cyclohexylprop-2-yn-1-ol (97563-45-6,105880-38-4,128241-52-1,4187-88-6) → C38H53NO5Si (105880-47-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / chromium trioxide, conc. sulfuric acid / acetone / 1 h / 0 °C

2: 1.) (S)-Alpine Borane, 2.) sodium hydroxide, 30 percent hydrogen peroxide / 1.) THF, 23 deg C, 16 h, 2.) THF, 40 deg C, 3 h

3: 71 percent / triethylamine / CH₂Cl₂ / 15 h / Ambient temperature

4: 1.) n-butyllithium, 2.) boron trifluoride etherate / 1.) THF, hexane, 2.) THF, hexane, -78 deg C

5: 39.3 percent / 4-(dimethylamino)pyridine, diisopropylethylamine / 8 h / 45 °C

With chromium(VI) oxide; dmap; sodium hydroxide; n-butyllithium; (S)-alpine borane; sulfuric acid; boron trifluoride diethyl etherate; dihydrogen peroxide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;

DOI:10.1021/jo00389a038

Reference yield:

cyclohexanecarbaldehyde (2043-61-0) → C38H53NO5Si (105880-47-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) ethylmagnesium bromide / 1.) THF, 2.) THF, 23 deg C, 16 h

2: 82 percent / chromium trioxide, conc. sulfuric acid / acetone / 1 h / 0 °C

3: 1.) (S)-Alpine Borane, 2.) sodium hydroxide, 30 percent hydrogen peroxide / 1.) THF, 23 deg C, 16 h, 2.) THF, 40 deg C, 3 h

4: 71 percent / triethylamine / CH₂Cl₂ / 15 h / Ambient temperature

5: 1.) n-butyllithium, 2.) boron trifluoride etherate / 1.) THF, hexane, 2.) THF, hexane, -78 deg C

6: 39.3 percent / 4-(dimethylamino)pyridine, diisopropylethylamine / 8 h / 45 °C

With chromium(VI) oxide; dmap; sodium hydroxide; n-butyllithium; (S)-alpine borane; sulfuric acid; boron trifluoride diethyl etherate; ethylmagnesium bromide; dihydrogen peroxide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;

DOI:10.1021/jo00389a038

upstream raw materials:

(R)-1-(1-naphthyl)ethyl isocyanate

C₂₅H₄₂O₄Si

1-cyclohexylprop-2-yn-1-ol

1-cyclohexyl-2-propyn-1-one

Downstream raw materials:

(1R,2S,3R,6S)-2-((R)-3-Cyclohexyl-3-hydroxy-prop-1-ynyl)-3-hydroxy-bicyclo[4.2.0]octan-7-one