8--8-aza-4-(1'-hydroxyethyl)-4-hydroxybicyclo<4.2.0>oct-2-ene

Base Information

Chemical Name:8--8-aza-4-(1'-hydroxyethyl)-4-hydroxybicyclo<4.2.0>oct-2-ene
CAS No.:120230-09-3
Molecular Formula:C₂₅H₂₈N₂O₄S
Molecular Weight:452.574
Hs Code.:

8-<N-(phenylsulfonyl)tryptophyl>-8-aza-4-(1'-hydroxyethyl)-4-hydroxybicyclo<4.2.0>oct-2-ene

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8--8-aza-4-(1'-hydroxyethyl)-4-hydroxybicyclo<4.2.0>oct-2-ene

Chemical Property:

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Technology Process of 8--8-aza-4-(1'-hydroxyethyl)-4-hydroxybicyclo<4.2.0>oct-2-ene

There total 5 articles about 8--8-aza-4-(1'-hydroxyethyl)-4-hydroxybicyclo<4.2.0>oct-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 120230-12-8
8--8-aza-4-acetyl-4-hydroxybicyclo<4.2.0>oct-2-ene

: 120230-09-3,120328-40-7
8--8-aza-4-(1'-hydroxyethyl)-4-hydroxybicyclo<4.2.0>oct-2-ene

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;
DOI:10.1021/jo00273a024

Reference yield:

: 120230-11-7
2--7-endo-acetylisoquinuclidene

: 120230-09-3,120328-40-7
8--8-aza-4-(1'-hydroxyethyl)-4-hydroxybicyclo<4.2.0>oct-2-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / potassium tert-butoxide, triethyl phosphite, O₂ / 2-methyl-propan-2-ol; 1,2-dimethoxy-ethane; CH₂Cl₂ / 3 h / -20 °C

2: 76 percent / NaBH₄ / methanol / 1 h / 0 °C

With sodium tetrahydroborate; potassium tert-butylate; oxygen; triethyl phosphite; In methanol; 1,2-dimethoxyethane; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00273a024

Reference yield:

: 120230-10-6
2--7-endo-<1,1-(ethylenedioxy)ethyl>isoquinuclidene

: 120230-09-3,120328-40-7
8--8-aza-4-(1'-hydroxyethyl)-4-hydroxybicyclo<4.2.0>oct-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / 10percent H₂SO₄, silica gel 60 / CH₂Cl₂ / 40 h / 25 °C

2: 79 percent / potassium tert-butoxide, triethyl phosphite, O₂ / 2-methyl-propan-2-ol; 1,2-dimethoxy-ethane; CH₂Cl₂ / 3 h / -20 °C

3: 76 percent / NaBH₄ / methanol / 1 h / 0 °C

With sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; oxygen; silica gel; triethyl phosphite; In methanol; 1,2-dimethoxyethane; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00273a024