(1S,R)-5-oxo-5-(phenylmethoxy)-1-<<<(2,2,2-trichloroethoxy)carbonyl>amino>methyl>phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

Base Information

Chemical Name:(1S,R)-5-oxo-5-(phenylmethoxy)-1-<<<(2,2,2-trichloroethoxy)carbonyl>amino>methyl>phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate
CAS No.:143508-54-7
Molecular Formula:C₃₄H₄₉Cl₃N₂O₉
Molecular Weight:736.13
Hs Code.:

(1S,R)-5-oxo-5-(phenylmethoxy)-1-<<<(2,2,2-trichloroethoxy)carbonyl>amino>methyl>phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

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Chemical Property of (1S,R)-5-oxo-5-(phenylmethoxy)-1-<<<(2,2,2-trichloroethoxy)carbonyl>amino>methyl>phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

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Technology Process of (1S,R)-5-oxo-5-(phenylmethoxy)-1-<<<(2,2,2-trichloroethoxy)carbonyl>amino>methyl>phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

There total 6 articles about (1S,R)-5-oxo-5-(phenylmethoxy)-1-<<<(2,2,2-trichloroethoxy)carbonyl>amino>methyl>phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133617-19-3,946390-77-8
2-(4-(benzyloxy)butyl)oxirane

: 143508-54-7,143508-55-8
(1S,R)-5-oxo-5-(phenylmethoxy)-1-<<<(2,2,2-trichloroethoxy)carbonyl>amino>methyl>phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

Guidance literature:: Multi-step reaction with 7 steps

1: lithium azide / dimethylformamide

2: H₂ / Raney nickel / methanol

3: 87 percent / sodium bicarbonate / tetrahydrofuran; H₂O

4: 92 percent / 4-(dimethylamino)pyridine (DMAP), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / CH₂Cl₂ / 0 °C

5: H₂ / 10 percent Pd/C / methanol / 760 Torr

6: pyridinium dichromate (PDC) / dimethylformamide / 48 h

7: 45 percent / potassium carbonate / acetone / 6 h / Heating

With dmap; dipyridinium dichromate; lithium azide; hydrogen; sodium hydrogencarbonate; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; nickel; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00099a004

Reference yield:

: 1-Amino-6-benzyloxy-hexan-2-ol

: 143508-54-7,143508-55-8
(1S,R)-5-oxo-5-(phenylmethoxy)-1-<<<(2,2,2-trichloroethoxy)carbonyl>amino>methyl>phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / sodium bicarbonate / tetrahydrofuran; H₂O

2: 92 percent / 4-(dimethylamino)pyridine (DMAP), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / CH₂Cl₂ / 0 °C

3: H₂ / 10 percent Pd/C / methanol / 760 Torr

4: pyridinium dichromate (PDC) / dimethylformamide / 48 h

5: 45 percent / potassium carbonate / acetone / 6 h / Heating

With dmap; dipyridinium dichromate; hydrogen; sodium hydrogencarbonate; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00099a004

Reference yield:

: 143508-19-4
1-Azido-6-benzyloxy-hexan-2-ol

: 143508-54-7,143508-55-8
(1S,R)-5-oxo-5-(phenylmethoxy)-1-<<<(2,2,2-trichloroethoxy)carbonyl>amino>methyl>phentyl (4S,5R)-4-(cyclohexylmethyl)-2,2-dimethyl-3-<(1,1-dimethylethoxy)carbonyl>-5-oxazolidinecarbxylate

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Raney nickel / methanol

2: 87 percent / sodium bicarbonate / tetrahydrofuran; H₂O

3: 92 percent / 4-(dimethylamino)pyridine (DMAP), 3-ethyl-1-<3-(dimethylamino)propyl>carbodiimide (EDC) / CH₂Cl₂ / 0 °C

4: H₂ / 10 percent Pd/C / methanol / 760 Torr

5: pyridinium dichromate (PDC) / dimethylformamide / 48 h

6: 45 percent / potassium carbonate / acetone / 6 h / Heating

With dmap; dipyridinium dichromate; hydrogen; sodium hydrogencarbonate; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; nickel; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00099a004