2-(β-thiocarbamoylhydrazino)cinchoninic acid anilide

Base Information

• Chemical Name: 2-(β-thiocarbamoylhydrazino)cinchoninic acid anilide
• CAS No.: 136354-32-0
• Molecular Formula: C₁₇H₁₅N₅OS
• Molecular Weight: 337.405
• Mol file: 136354-32-0.mol

Synonyms:

Chemical Property of 2-(β-thiocarbamoylhydrazino)cinchoninic acid anilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(β-thiocarbamoylhydrazino)cinchoninic acid anilide

There total 4 articles about 2-(β-thiocarbamoylhydrazino)cinchoninic acid anilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-chloro-quinoline-4-carboxylic acid phenyl-amide (135323-86-3) + thiosemicarbazide (79-19-6) → 3-thio-1,2,4-triazolo<4,3-a>quinoline-9-carboxylic acid anilide (136354-36-4) + 2-(β-thiocarbamoylhydrazino)cinchoninic acid anilide (136354-32-0)

Guidance literature:

In ethanol; for 6h; Heating;

DOI:10.1007/BF00480836

Reference yield:

2-quinolone-4-carboxylic acid (15733-89-8) → 2-(β-thiocarbamoylhydrazino)cinchoninic acid anilide (136354-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) PCl₅, 2.) triethylamine / 1.) 100 deg C, 2.) benzene, reflux, 1 h

2: 62 percent / ethanol / 6 h / Heating

With phosphorus pentachloride; triethylamine; In ethanol;

DOI:10.1007/BF00480836

Reference yield:

aniline (62-53-3) → 2-(β-thiocarbamoylhydrazino)cinchoninic acid anilide (136354-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) PCl₅, 2.) triethylamine / 1.) 100 deg C, 2.) benzene, reflux, 1 h

2: 62 percent / ethanol / 6 h / Heating

With phosphorus pentachloride; triethylamine; In ethanol;

DOI:10.1007/BF00480836

upstream raw materials:

2-chloro-quinoline-4-carboxylic acid phenyl-amide

thiosemicarbazide

2-quinolone-4-carboxylic acid

aniline

Refernces