(-)-3'-Epi-carba-thymidine

Base Information

Chemical Name:(-)-3'-Epi-carba-thymidine
CAS No.:7236-51-3
Molecular Formula:C₁₁H₁₆N₂O₄
Molecular Weight:240.259
Hs Code.:
NSC Number:644194
DSSTox Substance ID:DTXSID001138010

Synonyms:carbathymidine;carbathymidine, (-)-isomer;carbocyclic thymidine;D-carba T

Suppliers and Price of (-)-3'-Epi-carba-thymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (-)-3'-Epi-carba-thymidine

Chemical Property:

XLogP3:-0.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:240.11100700
Heavy Atom Count:17
Complexity:380

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2CC(C(C2)O)CO

Technology Process of (-)-3'-Epi-carba-thymidine

There total 7 articles about (-)-3'-Epi-carba-thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 87470-95-9,87508-25-6,104263-92-5,125353-61-9,125353-62-0
(+/-)-1-<(1α,3α,4α)-3-hydroxy-4-<(triphenylmethoxy)methyl>cyclopentyl>-5-methyl-2,4(1H,3H)-pyrimidinedione

: 7236-51-3,56906-85-5,61849-27-2,87508-26-7,114884-15-0,125353-60-8,125353-66-4
(+/-)-1-<(1α,3α,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-methyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: With acetic acid; at 100 ℃; for 0.25h;
DOI:10.1002/jhet.5570200329

Reference yield:

: 61849-27-2
(+/-)-1-<(1α,3β,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-methyl-2,4-(1H,3H)pyrimidinedione

: 7236-51-3,56906-85-5,61849-27-2,87508-26-7,114884-15-0,125353-60-8,125353-66-4
(+/-)-1-<(1α,3α,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-methyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / pyridine / 312 h / Ambient temperature

2: 78 percent / pyridine / 0 °C / overnight

3: 77 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene / acetonitrile / 17 h / Heating

4: 70 percent / aq. sodium hydroxide / ethanol / 2 h / Heating

5: 46 percent / 80 percent aq. acetic acid / 0.25 h / 100 °C

With sodium hydroxide; acetic acid; 1,5-Diazabicyclo[5.4.0]undec-5-ene; In pyridine; ethanol; acetonitrile;
DOI:10.1002/jhet.5570200329

Reference yield:

: 87491-47-2
8c-acetoxy-3-methyl-7,8,9,10-tetrahydro-6H-6r,9c-methano-pyrimido[2,1-b][1,3]oxazocin-2-one

: 7236-51-3,56906-85-5,61849-27-2,87508-26-7,114884-15-0,125353-60-8,125353-66-4
(+/-)-1-<(1α,3α,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl>-5-methyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / aq. sodium hydroxide / 2 h / Heating

2: 87 percent / pyridine / 312 h / Ambient temperature

3: 78 percent / pyridine / 0 °C / overnight

4: 77 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene / acetonitrile / 17 h / Heating

5: 70 percent / aq. sodium hydroxide / ethanol / 2 h / Heating

6: 46 percent / 80 percent aq. acetic acid / 0.25 h / 100 °C

With sodium hydroxide; acetic acid; 1,5-Diazabicyclo[5.4.0]undec-5-ene; In pyridine; ethanol; acetonitrile;
DOI:10.1002/jhet.5570200329