Technology Process of Methyl-((Z)-oxacyclopentadec-2-en-2-yl)-phenyl-amine
There total 8 articles about Methyl-((Z)-oxacyclopentadec-2-en-2-yl)-phenyl-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 97 percent / HCl / 3 h / 25 °C
2: 85 percent / diisopropylethylamine / 18 h / 150 °C / other reaction conditions
3: 1.) LiAlH4, 2.) H2O / 1.)Et2O, 2 h
4: methyltriphenoxyphosphonium iodide
5: 2.) NH4Cl/NH4OH / 1.) HMPA, THF, 70 deg C, 3 h, 2.) -40 deg C
6: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O
7: BF3 etherate / diethyl ether
With
hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; methyltriphenoxyphosphonium iodide; water; tert.-butyl lithium; ammonium chloride; N-ethyl-N,N-diisopropylamine;
boron trifluoride diethyl etherate;
In
diethyl ether;
DOI:10.1016/S0040-4039(00)92763-1
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 85 percent / diisopropylethylamine / 18 h / 150 °C / other reaction conditions
2: 1.) LiAlH4, 2.) H2O / 1.)Et2O, 2 h
3: methyltriphenoxyphosphonium iodide
4: 2.) NH4Cl/NH4OH / 1.) HMPA, THF, 70 deg C, 3 h, 2.) -40 deg C
5: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O
6: BF3 etherate / diethyl ether
With
ammonium hydroxide; lithium aluminium tetrahydride; methyltriphenoxyphosphonium iodide; water; tert.-butyl lithium; ammonium chloride; N-ethyl-N,N-diisopropylamine;
boron trifluoride diethyl etherate;
In
diethyl ether;
DOI:10.1016/S0040-4039(00)92763-1
- Guidance literature:
-
Multi-step reaction with 4 steps
1: methyltriphenoxyphosphonium iodide
2: 2.) NH4Cl/NH4OH / 1.) HMPA, THF, 70 deg C, 3 h, 2.) -40 deg C
3: 1.) t-butyllithium, 2.) NH4Cl/NH4OH / 1.) THF, from -78 deg C to 25 deg C and 15 min at room temperature, 2.) 40 deg C, H2O
4: BF3 etherate / diethyl ether
With
ammonium hydroxide; methyltriphenoxyphosphonium iodide; tert.-butyl lithium; ammonium chloride;
boron trifluoride diethyl etherate;
In
diethyl ether;
DOI:10.1016/S0040-4039(00)92763-1
