(3-Aminocyclobutyl)methanol hydrochloride

Base Information

• Chemical Name: (3-Aminocyclobutyl)methanol hydrochloride
• CAS No.: 142733-65-1
• Molecular Formula: C₅H₁₁NO*ClH
• Molecular Weight: 137.609
• Hs Code.: 2906190090
• European Community (EC) Number: 851-729-3,860-628-3,867-658-6
• DSSTox Substance ID: DTXSID50599994
• Mol file: 142733-65-1.mol

Synonyms:130369-06-1;142733-65-1;1284250-10-7;3-Amino-cyclobutanemethanol hydrochloride;(3-aminocyclobutyl)methanol hydrochloride;cis-3-Amino-cyclobutanemethanol hydrochloride;TRANS-3-AMINO-CYCLOBUTANEMETHANOL HYDROCHLORIDE;(cis-3-Aminocyclobutyl)methanol hydrochloride;((trans-3-Aminocyclobutyl)methanol hydrochloride;(3-aminocyclobutyl)methanol;hydrochloride;trans-3-Amino-cyclobutanemethanol HCl;3-Amino-cyclobutanemethanol HCl;Cyclobutanemethanol, 3-amino-, hydrochloride, cis-;MFCD16659926;MFCD16660356;(trans-3-aminocyclobutyl)methanol hydrochloride;MFCD22628707;3-aminocyclobutaneMethanol HCl;SCHEMBL1583642;SCHEMBL1583644;SCHEMBL19208551;DTXSID50599994;NGVZDZFNCCGDGQ-BPNVWSNHSA-N;3-Aminocyclobutanemethan-1-ol HCl;(cis-3-Aminocyclobutyl)methanol HCl;cis-3-Amino-cyclobutanemethanol HCl;trans-3-aminocyclobutanemethanol HCl;AKOS016009225;AKOS024438470;AKOS025290819;3-Aminocyclobutanemethanol hydrochloride;cis-3-Aminocyclobutanemethan-1-ol HCl;DS-4397;PB18381;PB19477;PB21400;(3-aminocyclobutyl)methanolhydrochloride;trans-3-Aminocyclobutanemethan-1-ol HCl;AS-33520;AS-33681;SY026882;SY098739;cis-3-Aminocyclobutanemethanol hydrochloride;CS-0045535;CS-0049714;CS-0053387;EN300-703023;A885139;A888764;A889019;Cyclobutanemethanol, 3-amino-, hydrochloride (1:1);(3-Aminocyclobutyl)methanol--hydrogen chloride (1/1);[(1R,3R)-3-AMINOCYCLOBUTYL]METHANOL HYDROCHLORIDE;Cyclobutanemethanol, 3-amino-, hydrochloride (1:1), trans-;3-AMINO-CYCLOBUTANEMETHANOL HYDROCHLORIDE[130369-06-1]

Chemical Property of (3-Aminocyclobutyl)methanol hydrochloride

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.0607417
• Heavy Atom Count: 8
• Complexity: 59.1

Purity/Quality:

97% ^*data from raw suppliers

cis-(3-Aminocyclobutyl)methanol hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CC1N)CO.Cl

Technology Process of (3-Aminocyclobutyl)methanol hydrochloride

There total 2 articles about (3-Aminocyclobutyl)methanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cis-3-hydroxymethyl-1-<(t-butoxycarbonyl)amino>cyclobutane (142733-64-0,167081-37-0) → cis-(3-aminocyclobutyl)methanol hydrochloride (142733-65-1)

Guidance literature:

With hydrogenchloride; In methanol; for 4h; Ambient temperature;

Reference yield:

cis-methyl 3-<(t-butoxycarbonyl)amino>cyclobutanecarboxylate (142733-63-9,1101173-77-6) → cis-(3-aminocyclobutyl)methanol hydrochloride (142733-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / CaCl₂, NaBH₄ / ethanol / 12 h / Ambient temperature

2: 100 percent / HCl / methanol / 4 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; calcium chloride; In methanol; ethanol;

Reference yield: 72.5%

cis-(3-aminocyclobutyl)methanol hydrochloride (142733-65-1) → cis-3-amino-1-cyclobutanemethanol (142733-66-2)

Guidance literature:

With Dowex 50W-X₄ cation exchange resin H⁺ form; In ethanol;

upstream raw materials:

cis-3-hydroxymethyl-1-<(t-butoxycarbonyl)amino>cyclobutane

cis-methyl 3-<(t-butoxycarbonyl)amino>cyclobutanecarboxylate

Downstream raw materials:

cis-3-amino-1-cyclobutanemethanol