1-phenyl-3-(2-pyridyl)thiobarbiturate

Base Information

• Chemical Name: 1-phenyl-3-(2-pyridyl)thiobarbiturate
• CAS No.: 78755-03-0
• Molecular Formula: C₁₅H₁₁N₃O₂S
• Molecular Weight: 297.337

Synonyms:

Chemical Property of 1-phenyl-3-(2-pyridyl)thiobarbiturate

Chemical Property:

Purity/Quality:

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Technology Process of 1-phenyl-3-(2-pyridyl)thiobarbiturate

There total 3 articles about 1-phenyl-3-(2-pyridyl)thiobarbiturate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-(2'-pyridyl)-3-phenylthiourea (886-60-2) + malonic acid (141-82-2) → 1-phenyl-3-(2-pyridyl)thiobarbiturate (78755-03-0)

Guidance literature:

With acetyl chloride; at 60 - 80 ℃; for 1h;

DOI:10.1002/jhet.5570180341

Reference yield:

2-aminopyridine (504-29-0) → 1-phenyl-3-(2-pyridyl)thiobarbiturate (78755-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 2 h / Heating

2: 72 percent / CH₃COCl / 1 h / 60 - 80 °C

With acetyl chloride; In benzene;

DOI:10.1002/jhet.5570180341

Reference yield:

phenyl isothiocyanate (103-72-0) → 1-phenyl-3-(2-pyridyl)thiobarbiturate (78755-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 2 h / Heating

2: 72 percent / CH₃COCl / 1 h / 60 - 80 °C

With acetyl chloride; In benzene;

DOI:10.1002/jhet.5570180341

upstream raw materials:

1-(2'-pyridyl)-3-phenylthiourea

malonic acid

2-aminopyridine

phenyl isothiocyanate

Downstream raw materials:

5-[(4-Chloro-phenylamino)-methyl]-1-phenyl-3-pyridin-2-yl-2-thioxo-dihydro-pyrimidine-4,6-dione

5-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-1-phenyl-3-pyridin-2-yl-2-thioxo-dihydro-pyrimidine-4,6-dione

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