9,11,15-Tris(p-phenylbenzoyl)-12-epi-PGF_2β-methylester

Base Information

Chemical Name:9,11,15-Tris(p-phenylbenzoyl)-12-epi-PGF_2β-methylester
CAS No.:99958-35-7
Molecular Formula:C₆₀H₆₀O₈
Molecular Weight:909.132
Hs Code.:

9,11,15-Tris(p-phenylbenzoyl)-12-epi-PGF<sub>2β</sub>-methylester

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Chemical Property of 9,11,15-Tris(p-phenylbenzoyl)-12-epi-PGF_2β-methylester

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Technology Process of 9,11,15-Tris(p-phenylbenzoyl)-12-epi-PGF_2β-methylester

There total 19 articles about 9,11,15-Tris(p-phenylbenzoyl)-12-epi-PGF_2β-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36969-89-8
dimethyl 2-oxoheptylphosphonate

: 99958-35-7
9,11,15-Tris(p-phenylbenzoyl)-12-epi-PGF_2β-methylester

Guidance literature:: Multi-step reaction with 11 steps

1: 1) NaH (80percent in oil) / 1) anh. DME, r. t., 1 h, 2) DME, 40 deg C, 4 h

2: 93 percent / pyridine / 1) 1 h, 0 deg C, 2) 1 h, r. t.

3: 38 percent / ZnCl₂; NaBH₄ / 1,2-dimethoxy-ethane / 1) 1.5 h, -20 deg C, 2) 1 h, 0 deg C, 3) 3 h, r. t.

4: 2percent p-toluenesulfonic acid / CH₂Cl₂; tetrahydrofuran / 3 h

5: K₂CO₃ / methanol / 2.5 h / 35 °C

6: pyridinium-chlorochromate/Al₂O₃, anh. Na-acetate / CH₂Cl₂ / 3 h

7: 1) K-tert-butylate / 1) anh. THF, 30 min, r. t., 2) anh. THF, 5 min, -78 deg C; 40 min, 0 deg C

8: 59 percent / acetic acid; H₂O; tetrahydrofuran / 5 h / 40 °C

9: 82 percent / Na/liq. NH₃ / diethyl ether / 1 h

10: diethyl ether / 0 °C

11: pyridine

With aluminum oxide; sodium tetrahydroborate; potassium tert-butylate; ammonia; sodium acetate; sodium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; zinc(II) chloride; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; acetic acid;
DOI:10.1002/jlac.198319831215

Reference yield:

: 74552-31-1
(6R,7R)-(-)-7-Hydroxy-3-oxabicyclo<4.3.0>non-1-en-9-on

: 99958-35-7
9,11,15-Tris(p-phenylbenzoyl)-12-epi-PGF_2β-methylester

Guidance literature:: Multi-step reaction with 15 steps

1: 16 g / TEA / tetrahydrofuran / 5 h / Ambient temperature

2: 11.3 g / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

3: 1) NaH (80percent in oil) / 1) DMF, 0.5 h, -5 deg C, 2) 3 h, r. t.

4: 90 percent / Hg(II)-acetate, Hg(II)-oxide / H₂O; acetone / 1 h

5: 1) NaH (80percent in oil) / 1) anh. DME, r. t., 1 h, 2) DME, 40 deg C, 4 h

6: 93 percent / pyridine / 1) 1 h, 0 deg C, 2) 1 h, r. t.

7: 38 percent / ZnCl₂; NaBH₄ / 1,2-dimethoxy-ethane / 1) 1.5 h, -20 deg C, 2) 1 h, 0 deg C, 3) 3 h, r. t.

8: 2percent p-toluenesulfonic acid / CH₂Cl₂; tetrahydrofuran / 3 h

9: K₂CO₃ / methanol / 2.5 h / 35 °C

10: pyridinium-chlorochromate/Al₂O₃, anh. Na-acetate / CH₂Cl₂ / 3 h

11: 1) K-tert-butylate / 1) anh. THF, 30 min, r. t., 2) anh. THF, 5 min, -78 deg C; 40 min, 0 deg C

12: 59 percent / acetic acid; H₂O; tetrahydrofuran / 5 h / 40 °C

13: 82 percent / Na/liq. NH₃ / diethyl ether / 1 h

14: diethyl ether / 0 °C

15: pyridine

With aluminum oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; TEA; potassium tert-butylate; mercury(II) diacetate; ammonia; sodium acetate; sodium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; mercury(II) oxide; zinc(II) chloride; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; acetic acid; acetone;
DOI:10.1002/jlac.198319831215

Reference yield:

: 82207-78-1,82468-14-2,85249-05-4,105499-64-7
(1S,6R,7R)-(-)-2-(Benzylthio)-7-hydroxy-3-oxabicyclo<4.3.0>nonan-9-on

: 99958-35-7
9,11,15-Tris(p-phenylbenzoyl)-12-epi-PGF_2β-methylester

Guidance literature:: Multi-step reaction with 14 steps

1: 11.3 g / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

2: 1) NaH (80percent in oil) / 1) DMF, 0.5 h, -5 deg C, 2) 3 h, r. t.

3: 90 percent / Hg(II)-acetate, Hg(II)-oxide / H₂O; acetone / 1 h

4: 1) NaH (80percent in oil) / 1) anh. DME, r. t., 1 h, 2) DME, 40 deg C, 4 h

5: 93 percent / pyridine / 1) 1 h, 0 deg C, 2) 1 h, r. t.

6: 38 percent / ZnCl₂; NaBH₄ / 1,2-dimethoxy-ethane / 1) 1.5 h, -20 deg C, 2) 1 h, 0 deg C, 3) 3 h, r. t.

7: 2percent p-toluenesulfonic acid / CH₂Cl₂; tetrahydrofuran / 3 h

8: K₂CO₃ / methanol / 2.5 h / 35 °C

9: pyridinium-chlorochromate/Al₂O₃, anh. Na-acetate / CH₂Cl₂ / 3 h

10: 1) K-tert-butylate / 1) anh. THF, 30 min, r. t., 2) anh. THF, 5 min, -78 deg C; 40 min, 0 deg C

11: 59 percent / acetic acid; H₂O; tetrahydrofuran / 5 h / 40 °C

12: 82 percent / Na/liq. NH₃ / diethyl ether / 1 h

13: diethyl ether / 0 °C

14: pyridine

With aluminum oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; potassium tert-butylate; mercury(II) diacetate; ammonia; sodium acetate; sodium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; mercury(II) oxide; zinc(II) chloride; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; acetic acid; acetone;
DOI:10.1002/jlac.198319831215