4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-1-{cyclooctyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-benzamide

Base Information

Chemical Name:4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-1-{cyclooctyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-benzamide
CAS No.:129585-39-3
Molecular Formula:C₃₅H₄₄ClF₃N₄O₇S
Molecular Weight:757.271
Hs Code.:

4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-1-{cyclooctyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-benzamide

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Chemical Property of 4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-1-{cyclooctyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-benzamide

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Technology Process of 4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-1-{cyclooctyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-benzamide

There total 8 articles about 4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-1-{cyclooctyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-1-{cyclooctyl-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-benzamide

: 129585-39-3,137302-16-0
4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-1-{cyclooctyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-benzamide

Guidance literature:: With Dess-Martin periodane; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00082a005

Reference yield:

: 98-64-6
4-Chlorobenzenesulfonamide

: 129585-39-3,137302-16-0
4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-1-{cyclooctyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 42.3 percent / DMAP, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / CH₂Cl₂

2: 63 percent / CF₃COOH

3: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

4: Dess-Martin periodinane reagent, CF₃COOH / tetrahydrofuran; CH₂Cl₂ / 16 h / Ambient temperature

With dmap; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00082a005

Reference yield:

: 28313-42-0
di-tert-butyl terephthalate

: 129585-39-3,137302-16-0
4-(4-Chloro-benzenesulfonylaminocarbonyl)-N-((S)-1-{cyclooctyl-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-carbamoyl}-2-methyl-propyl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / KOH / 2-methyl-propan-2-ol

2: 42.3 percent / DMAP, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / CH₂Cl₂

3: 63 percent / CF₃COOH

4: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

5: Dess-Martin periodinane reagent, CF₃COOH / tetrahydrofuran; CH₂Cl₂ / 16 h / Ambient temperature

With dmap; potassium hydroxide; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm00082a005