(1S,2R,3S,4R)-4-[6-Amino-2-(2-cyclohexyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide

Base Information

• Chemical Name: (1S,2R,3S,4R)-4-[6-Amino-2-(2-cyclohexyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide
• CAS No.: 116856-32-7
• Molecular Formula: C₂₁H₃₃N₇O₃
• Molecular Weight: 431.538
• Mol file: 116856-32-7.mol

Synonyms:

Chemical Property of (1S,2R,3S,4R)-4-[6-Amino-2-(2-cyclohexyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,3S,4R)-4-[6-Amino-2-(2-cyclohexyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide

There total 6 articles about (1S,2R,3S,4R)-4-[6-Amino-2-(2-cyclohexyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aza-bicyclo<2.2.1><(dimethylmethylene)dioxy-trans-5,6>-one-3-heptane (116856-49-6,127061-47-6,130468-01-8,130468-02-9,220507-10-8) → (1S,2R,3S,4R)-4-[6-Amino-2-(2-cyclohexyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide (116856-32-7,132342-42-8)

Guidance literature:

Multi-step reaction with 5 steps

1: neat (no solvent) / 140 °C / in steel bomb

2: 83 percent / butan-1-ol / Heating

3: 2.) NH₃

4: 100 percent / 1N HCl

5: 5 h / 140 °C

With hydrogenchloride; ammonia; In butan-1-ol;

DOI:10.1016/S0040-4039(01)93795-5

Reference yield:

exo-cis-5,6-Dihydroxy-2-azabicyclo<2.2.1>heptan-3-one (77745-22-3) → (1S,2R,3S,4R)-4-[6-Amino-2-(2-cyclohexyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide (116856-32-7,132342-42-8)

Guidance literature:

Multi-step reaction with 6 steps

2: neat (no solvent) / 140 °C / in steel bomb

3: 83 percent / butan-1-ol / Heating

4: 2.) NH₃

5: 100 percent / 1N HCl

6: 5 h / 140 °C

With hydrogenchloride; ammonia; In butan-1-ol;

DOI:10.1016/S0040-4039(01)93795-5

Reference yield:

(3aR,4S,6R,6aS)-6-Amino-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole-4-carboxylic acid ethylamide (116909-60-5) → (1S,2R,3S,4R)-4-[6-Amino-2-(2-cyclohexyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide (116856-32-7,132342-42-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / butan-1-ol / Heating

2: 2.) NH₃

3: 100 percent / 1N HCl

4: 5 h / 140 °C

With hydrogenchloride; ammonia; In butan-1-ol;

DOI:10.1016/S0040-4039(01)93795-5

upstream raw materials:

2-cyclohexylethylamine

(1S,2R,3S,4R)-4-(6-Amino-2-chloro-purin-9-yl)-2,3-dihydroxy-cyclopentanecarboxylic acid ethylamide; hydrochloride

aza-bicyclo<2.2.1><(dimethylmethylene)dioxy-trans-5,6>-one-3-heptane

(3aR,4S,6R,6aS)-6-(6-Amino-2-chloro-purin-9-yl)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxole-4-carboxylic acid ethylamide