Cyclobutanecarboxylic acid, 3-methyl-3-(phenylthio)-, 1,1-dimethylethyl ester, trans-

Base Information

• Chemical Name: Cyclobutanecarboxylic acid, 3-methyl-3-(phenylthio)-, 1,1-dimethylethyl ester, trans-
• CAS No.: 136571-46-5
• Molecular Formula: C16H22O2S
• Molecular Weight: 278.415
• Mol file: 136571-46-5.mol

Synonyms:

Chemical Property of Cyclobutanecarboxylic acid, 3-methyl-3-(phenylthio)-, 1,1-dimethylethyl ester, trans-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclobutanecarboxylic acid, 3-methyl-3-(phenylthio)-, 1,1-dimethylethyl ester, trans-

There total 3 articles about Cyclobutanecarboxylic acid, 3-methyl-3-(phenylthio)-, 1,1-dimethylethyl ester, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

potassium tert-butylate (865-47-4) + methyl (E)-3-methyl-3-phenylthio-1-cyclobutanecarboxylate (76185-74-5) → tert-butyl 3-methyl-3-phenylthio-1-cyclobutanecarboxylate (136571-46-5)

Guidance literature:

In diethyl ether; at 20 ℃;

DOI:10.1055/s-2001-13356

Reference yield:

tert-butyl 3-methylbicyclobutane-1-carboxylate (30493-93-7) + potassium thiophenolate (3111-52-2) → tert-butyl 3-methyl-3-phenylthio-1-cyclobutanecarboxylate (136571-46-5) + tert-butyl 3-methyl-3-phenylthio-1-cyclobutanecarboxylate (136571-49-8)

Guidance literature:

In tert-butyl alcohol; at 20 ℃; for 20h; Yield given. Yields of byproduct given;

Reference yield:

tert-butyl 3-methylbicyclobutane-1-carboxylate (30493-93-7) + thiophenol (108-98-5) → tert-butyl 3-methyl-3-phenylthio-1-cyclobutanecarboxylate (136571-46-5) + tert-butyl 3-methyl-3-phenylthio-1-cyclobutanecarboxylate (136571-49-8) + tert-butyl 3-methyl-1-phenylthio-1-cyclobutanecarboxylate (136571-43-2) + tert-butyl 3-methyl-1-phenylthio-1-cyclobutanecarboxylate (136571-38-5)

Guidance literature:

In tetrachloromethane; at 20 ℃; for 20h;

upstream raw materials:

tert-butyl 3-methylbicyclobutane-1-carboxylate

potassium thiophenolate

thiophenol

potassium tert-butylate

Refernces

• 1、 Vasin, V. A.,Razin, V. V.,Bolusheva, I. Yu.,Tanaseichuk, B. S.,Surmina, L. S.,Zefirov, N. S.. "REGIOSELECTIVITY OF THE ADDITION OF THIOLS TO 1-R-3-METHYLBICYCLOBUTANES". . p. 469 - 477. Retrieved 2007/10/02.