Technology Process of 5-Benzyloxy-7-methoxy-9,10-dihydro-phenanthren-3-ol
There total 12 articles about 5-Benzyloxy-7-methoxy-9,10-dihydro-phenanthren-3-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1: oxalyl chloride / DMF / benzene / 0.5 h / Ambient temperature
2: diethyl ether
3: Ag2O / 3 h / 60 °C
4: 96 percent / KOH / methanol; H2O / 3 h
5: 87 percent / polyphosphoric acid / 4 h / 100 - 110 °C
6: 77 percent / BCl3 / CH2Cl2 / 1.) -78 deg. C; 2.) room temperature, 0.5 h
7: 95 percent / K2CO3 / acetone / 24 h / Heating
8: 100 percent / NaOMe
9: 100 percent / triethylamine / benzene / 168 h
10: NaOEt / ethanol / 3 h
11: 60 percent / NaH / tetrahydrofuran / 24 h
12: pyridinium bromide perbromide / acetic acid / 0.5 h
With
potassium hydroxide; PPA; oxalyl dichloride; sodium methylate; sodium ethanolate; pyridinium hydrobromide perbromide; boron trichloride; sodium hydride; potassium carbonate; triethylamine; silver(l) oxide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetic acid; acetone; benzene;
DOI:10.1139/v85-367
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 77 percent / BCl3 / CH2Cl2 / 1.) -78 deg. C; 2.) room temperature, 0.5 h
2: 95 percent / K2CO3 / acetone / 24 h / Heating
3: 100 percent / NaOMe
4: 100 percent / triethylamine / benzene / 168 h
5: NaOEt / ethanol / 3 h
6: 60 percent / NaH / tetrahydrofuran / 24 h
7: pyridinium bromide perbromide / acetic acid / 0.5 h
With
sodium methylate; sodium ethanolate; pyridinium hydrobromide perbromide; boron trichloride; sodium hydride; potassium carbonate; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; acetic acid; acetone; benzene;
DOI:10.1139/v85-367
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 87 percent / polyphosphoric acid / 4 h / 100 - 110 °C
2: 77 percent / BCl3 / CH2Cl2 / 1.) -78 deg. C; 2.) room temperature, 0.5 h
3: 95 percent / K2CO3 / acetone / 24 h / Heating
4: 100 percent / NaOMe
5: 100 percent / triethylamine / benzene / 168 h
6: NaOEt / ethanol / 3 h
7: 60 percent / NaH / tetrahydrofuran / 24 h
8: pyridinium bromide perbromide / acetic acid / 0.5 h
With
PPA; sodium methylate; sodium ethanolate; pyridinium hydrobromide perbromide; boron trichloride; sodium hydride; potassium carbonate; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; acetic acid; acetone; benzene;
DOI:10.1139/v85-367
