Tosylate of (5S,10S,15R)-12-Methoxy-8,11,13-abietatrien-16-ol

Base Information

Chemical Name:Tosylate of (5S,10S,15R)-12-Methoxy-8,11,13-abietatrien-16-ol
CAS No.:96641-66-6
Molecular Formula:C₂₈H₃₈O₄S
Molecular Weight:470.673
Hs Code.:

Synonyms:

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Chemical Property of Tosylate of (5S,10S,15R)-12-Methoxy-8,11,13-abietatrien-16-ol

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Technology Process of Tosylate of (5S,10S,15R)-12-Methoxy-8,11,13-abietatrien-16-ol

There total 18 articles about Tosylate of (5S,10S,15R)-12-Methoxy-8,11,13-abietatrien-16-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96641-55-3
<(R)-4-Methoxy-3-(2-methoxy-1-methylethyl)benzyl>triphenylphosphonium chloride

: 96641-66-6,96641-67-7
Tosylate of (5S,10S,15R)-12-Methoxy-8,11,13-abietatrien-16-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1)BuLi / 1)hexane,benzene, room temp. 15 min., 2) room temp. 1.5 h;

2: 94.1 percent / H₂ / 5percentPd-C / ethanol / Ambient temperature

3: 49 percent / AlCl₃ / benzene / 0.83 h / Ambient temperature

4: 95.7 percent / AlCl₃,NaI / CH₂Cl₂; acetonitrile / 1) 0-5 deg C 15 min. 2) 35-40 dec C 5h;

5: 95.6 percent / K₂CO₃ / butan-2-one / 5 h / Heating

6: 50.0 mg / pyridine / 3.5 h / 70 - 75 °C

With pyridine; n-butyllithium; aluminium trichloride; hydrogen; potassium carbonate; sodium iodide; 5% Pd on active carbon; In ethanol; dichloromethane; acetonitrile; butanone; benzene;
DOI:10.1246/bcsj.58.340

Reference yield:

: 96641-52-0
(S)-(+)-1-Methoxy-2-(2-methoxyphenyl)propane

: 96641-66-6,96641-67-7
Tosylate of (5S,10S,15S)-12-Methoxy-8,11,13-abietatrien-16-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 5.90 g / AcOH / 6 h / 35 - 40 °C

2: 11.92 g / benzene / 1.5 h / Heating

3: 1)BuLi / 1)hexane,benzene, 10-20 deg C,5 min., 2) room temp. 1.5 h;

4: 89.4 percent / H₂ / 10percentPd-C / methanol / Ambient temperature

5: 50.8 percent / AlCl₃ / benzene / 0.83 h / Ambient temperature

6: 95.5 percent / AlCl₃,NaI / CH₂Cl₂; acetonitrile / 1) 0-5 deg C 15 min. 2) 35-40 dec C 5h;

7: 92.3 percent / K₂CO₃ / butan-2-one / 5 h / Heating

8: 73.0 mg / pyridine / 3.5 h / 70 - 75 °C

With pyridine; n-butyllithium; aluminium trichloride; hydrogen; potassium carbonate; acetic acid; sodium iodide; 10% palladium on active carbon; In methanol; dichloromethane; acetonitrile; butanone; benzene;
DOI:10.1246/bcsj.58.340

Reference yield:

: 96641-51-9
(R)-(-)-1-Methoxy-2-(2-methoxyphenyl)propane

: 96641-66-6,96641-67-7
Tosylate of (5S,10S,15R)-12-Methoxy-8,11,13-abietatrien-16-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 5.00 g / AcOH / 6 h / 35 - 40 °C

2: 10.29 g / benzene / 1 h / Heating

3: 1)BuLi / 1)hexane,benzene, room temp. 15 min., 2) room temp. 1.5 h;

4: 94.1 percent / H₂ / 5percentPd-C / ethanol / Ambient temperature

5: 49 percent / AlCl₃ / benzene / 0.83 h / Ambient temperature

6: 95.7 percent / AlCl₃,NaI / CH₂Cl₂; acetonitrile / 1) 0-5 deg C 15 min. 2) 35-40 dec C 5h;

7: 95.6 percent / K₂CO₃ / butan-2-one / 5 h / Heating

8: 50.0 mg / pyridine / 3.5 h / 70 - 75 °C

With pyridine; n-butyllithium; aluminium trichloride; hydrogen; potassium carbonate; acetic acid; sodium iodide; 5% Pd on active carbon; In ethanol; dichloromethane; acetonitrile; butanone; benzene;
DOI:10.1246/bcsj.58.340