N-(3,3,3-Trifluoro-2-hydroxy-1-isopropyl-propyl)-2-(2,4,8-trioxo-3-phenethyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl)-acetamide

Base Information

Chemical Name:N-(3,3,3-Trifluoro-2-hydroxy-1-isopropyl-propyl)-2-(2,4,8-trioxo-3-phenethyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl)-acetamide
CAS No.:159780-41-3
Molecular Formula:C₂₃H₂₅F₃N₄O₅
Molecular Weight:494.471
Hs Code.:

N-(3,3,3-Trifluoro-2-hydroxy-1-isopropyl-propyl)-2-(2,4,8-trioxo-3-phenethyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl)-acetamide

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Chemical Property of N-(3,3,3-Trifluoro-2-hydroxy-1-isopropyl-propyl)-2-(2,4,8-trioxo-3-phenethyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl)-acetamide

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Technology Process of N-(3,3,3-Trifluoro-2-hydroxy-1-isopropyl-propyl)-2-(2,4,8-trioxo-3-phenethyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl)-acetamide

There total 17 articles about N-(3,3,3-Trifluoro-2-hydroxy-1-isopropyl-propyl)-2-(2,4,8-trioxo-3-phenethyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33707-21-0
dimethyl <3-(dimethylamino)-2-(ethoxycarbonyl)-2-propenylidene>malonate

: 159780-41-3
N-(3,3,3-Trifluoro-2-hydroxy-1-isopropyl-propyl)-2-(2,4,8-trioxo-3-phenethyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl)-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 71 percent / ethanol / 16 h / Heating

2: LiI / pyridine / 14 h / Heating

3: diphenyl phosphorazidate, TEA / dioxane / 4 h / Heating

4: aq. LiOH*H₂O / ethanol / 7 h / 0 °C

5: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature

6: dimethylformamide / 2.5 h / 120 °C

7: TBAF / tetrahydrofuran / 2 h / Ambient temperature

With lithium hydroxide; TEA; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z

Reference yield:

: 106746-09-2
3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

: 159780-41-3
N-(3,3,3-Trifluoro-2-hydroxy-1-isopropyl-propyl)-2-(2,4,8-trioxo-3-phenethyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl)-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1: NMM / tetrahydrofuran / 3 h / 0 °C

2: 62 percent / 2,6-lutidine / CH₂Cl₂ / 3 h / Ambient temperature

3: 96 percent / NaI / acetone / 16 h / Ambient temperature

4: 58 percent / DBU / dimethylformamide / 24 h / Ambient temperature

5: LiI / pyridine / 14 h / Heating

6: diphenyl phosphorazidate, TEA / dioxane / 4 h / Heating

7: aq. LiOH*H₂O / ethanol / 7 h / 0 °C

8: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature

9: dimethylformamide / 2.5 h / 120 °C

10: TBAF / tetrahydrofuran / 2 h / Ambient temperature

With 4-methyl-morpholine; 2,6-dimethylpyridine; lithium hydroxide; TEA; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; lithium iodide; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm950684z

Reference yield:

: 174740-67-1
dimethyl <2-(ethoxycarbonyl)ethylidene>malonate

: 159780-41-3
N-(3,3,3-Trifluoro-2-hydroxy-1-isopropyl-propyl)-2-(2,4,8-trioxo-3-phenethyl-2,3,4,8-tetrahydro-1H-pyrido[3,4-d]pyrimidin-7-yl)-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / dimethylformamide / 3 h / 80 °C

2: 71 percent / ethanol / 16 h / Heating

3: LiI / pyridine / 14 h / Heating

4: diphenyl phosphorazidate, TEA / dioxane / 4 h / Heating

5: aq. LiOH*H₂O / ethanol / 7 h / 0 °C

6: HOBt, EDAC / dimethylformamide / 16 h / Ambient temperature

7: dimethylformamide / 2.5 h / 120 °C

8: TBAF / tetrahydrofuran / 2 h / Ambient temperature

With lithium hydroxide; TEA; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950684z