Technology Process of methyl 3α-tosyloxy-5β-androst-8(14)-en-17β-carboxylate
There total 11 articles about methyl 3α-tosyloxy-5β-androst-8(14)-en-17β-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 85 percent / N-lithioethylenediamine / ethane-1,2-diamine / 0.25 h / Heating
2: 90 percent / HCl / 2 h / Heating
3: 1.) ozone, 2.) Jones' reagent / 1.) CH2Cl2, -10 deg C, 2.) acetone, 0 deg C
4: 71 percent / BF3*Et20 / methanol; benzene / 24 h / Ambient temperature
6: pyridine / 1 h / Heating
7: methanol
8: 1.) ZnCl2 / 1.) acetone, 2.) methanol
9: 1.) KOH / 1.) etanol, reflux, 6 h, 2.) metanol
10: 74 percent / pyridine / 24 h / Ambient temperature
With
pyridine; potassium hydroxide; jones' reagent; boron trifluoride diethyl etherate; lithium 2-aminoethylamide; ozone; zinc(II) chloride;
hydrogenchloride;
In
pyridine; methanol; ethylenediamine; benzene;
DOI:10.1002/hlca.19860690810
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 90 percent / HCl / 2 h / Heating
2: 1.) ozone, 2.) Jones' reagent / 1.) CH2Cl2, -10 deg C, 2.) acetone, 0 deg C
3: 71 percent / BF3*Et20 / methanol; benzene / 24 h / Ambient temperature
5: pyridine / 1 h / Heating
6: methanol
7: 1.) ZnCl2 / 1.) acetone, 2.) methanol
8: 1.) KOH / 1.) etanol, reflux, 6 h, 2.) metanol
9: 74 percent / pyridine / 24 h / Ambient temperature
With
pyridine; potassium hydroxide; jones' reagent; boron trifluoride diethyl etherate; ozone; zinc(II) chloride;
hydrogenchloride;
In
pyridine; methanol; benzene;
DOI:10.1002/hlca.19860690810
