6α-<2,4-dimethoxy-5-(2-methoxyethoxy)phenyl>-2β-(2,6-dimethoxyphenoxy)-1α-hydroxy-3,7-dioxabicyclo<3.3.0>octane

Base Information

Chemical Name:6α-<2,4-dimethoxy-5-(2-methoxyethoxy)phenyl>-2β-(2,6-dimethoxyphenoxy)-1α-hydroxy-3,7-dioxabicyclo<3.3.0>octane
CAS No.:142206-73-3
Molecular Formula:C₂₅H₃₂O₁₀
Molecular Weight:492.523
Hs Code.:

Synonyms:

Suppliers and Price of 6α-<2,4-dimethoxy-5-(2-methoxyethoxy)phenyl>-2β-(2,6-dimethoxyphenoxy)-1α-hydroxy-3,7-dioxabicyclo<3.3.0>octane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6α-<2,4-dimethoxy-5-(2-methoxyethoxy)phenyl>-2β-(2,6-dimethoxyphenoxy)-1α-hydroxy-3,7-dioxabicyclo<3.3.0>octane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6α-<2,4-dimethoxy-5-(2-methoxyethoxy)phenyl>-2β-(2,6-dimethoxyphenoxy)-1α-hydroxy-3,7-dioxabicyclo<3.3.0>octane

There total 53 articles about 6α-<2,4-dimethoxy-5-(2-methoxyethoxy)phenyl>-2β-(2,6-dimethoxyphenoxy)-1α-hydroxy-3,7-dioxabicyclo<3.3.0>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: tert-Butyl-[(1R,3aR,4S,6aS)-1-[2,4-dimethoxy-5-(2-methoxy-ethoxy)-phenyl]-4-(2,6-dimethoxy-phenoxy)-dihydro-furo[3,4-c]furan-3a-yloxy]-dimethyl-silane

: 142206-73-3,142291-86-9
6α-<2,4-dimethoxy-5-(2-methoxyethoxy)phenyl>-2α-(2,6-dimethoxyphenoxy)-1α-hydroxy-3,7-dioxabicyclo<3.3.0>octane

Guidance literature:: With tetrabutyl ammonium fluoride; for 3h;

Reference yield:

: 2-benzyloxy-4-methoxy-1-(2-methoxyethoxy)benzene

: 142206-73-3,142291-86-9
6α-<2,4-dimethoxy-5-(2-methoxyethoxy)phenyl>-2α-(2,6-dimethoxyphenoxy)-1α-hydroxy-3,7-dioxabicyclo<3.3.0>octane

Guidance literature:: Multi-step reaction with 18 steps

1: 83 percent / POCl₃ / 1 h / 60 °C

2: 47 percent / i-Pr₂NLi / tetrahydrofuran / 2 h / -75 °C

3: 86 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

4: 67 percent / LiAlH₄ / diethyl ether / 0.5 h / -10 °C

5: 1) 2percent aq. OsO₄, N-methylmorpholine N-oxide, 2) NaIO₄ / 1) acetone, t-BuOH, r.t., 16 h, 2) EtOAc, H₂O, r.t., 2 h

6: 93 percent / Ag₂CO₃, celite / benzene / 0.5 h / Heating

7: 1) Et₃N, MeSO₂Cl, 2) Et₃N / 1) benzene, r.t., 2 h, 2) benzene, r.t., 16 h

8: 98 percent / N-methylmorpholine N-oxide, 2percent aq. OsO₄ / acetone; 2-methyl-propan-2-ol / 24 h / Ambient temperature

9: 94 percent / Bu₄NF / tetrahydrofuran / 1 h / 0 °C

10: 57 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 16 h / Ambient temperature

11: 82 percent / H₂ / Pd/C / ethyl acetate / 4 h / 760 Torr / Ambient temperature

12: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / Ambient temperature

13: 69 percent / DIBAL-H / toluene / 0.5 h / -75 °C

14: 74 percent / 2-fluoro-1-methylpyridinium tosylate, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

15: 66 percent / trimethylsilyl trifluoromethanesulfonate / diethyl ether / 7 h / 0 °C

16: 40 percent / Bu₄NF / tetrahydrofuran; acetonitrile / 3 h / Ambient temperature

17: 58 percent / 7 h

18: 91 percent / Bu₄NF / 3 h

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; Celite; (1S)-10-camphorsulfonic acid; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; 1-methyl-2-fluoropyridinium p-toluenesulfonate; methanesulfonyl chloride; 4-methylmorpholine N-oxide; triethylamine; silver carbonate; lithium diisopropyl amide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; acetone; toluene; acetonitrile; tert-butyl alcohol; benzene;

Reference yield:

: 2-benzyloxy-4-methoxy-1-(2-methoxyethoxy)benzene

: 142206-73-3,142291-86-9
6α-<2,4-dimethoxy-5-(2-methoxyethoxy)phenyl>-2β-(2,6-dimethoxyphenoxy)-1α-hydroxy-3,7-dioxabicyclo<3.3.0>octane

Guidance literature:: Multi-step reaction with 17 steps

1: 83 percent / POCl₃ / 1 h / 60 °C

2: 47 percent / i-Pr₂NLi / tetrahydrofuran / 2 h / -75 °C

3: 86 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

4: 67 percent / LiAlH₄ / diethyl ether / 0.5 h / -10 °C

5: 1) 2percent aq. OsO₄, N-methylmorpholine N-oxide, 2) NaIO₄ / 1) acetone, t-BuOH, r.t., 16 h, 2) EtOAc, H₂O, r.t., 2 h

6: 93 percent / Ag₂CO₃, celite / benzene / 0.5 h / Heating

7: 1) Et₃N, MeSO₂Cl, 2) Et₃N / 1) benzene, r.t., 2 h, 2) benzene, r.t., 16 h

8: 98 percent / N-methylmorpholine N-oxide, 2percent aq. OsO₄ / acetone; 2-methyl-propan-2-ol / 24 h / Ambient temperature

9: 94 percent / Bu₄NF / tetrahydrofuran / 1 h / 0 °C

10: 57 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 16 h / Ambient temperature

11: 82 percent / H₂ / Pd/C / ethyl acetate / 4 h / 760 Torr / Ambient temperature

12: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / Ambient temperature

13: 69 percent / DIBAL-H / toluene / 0.5 h / -75 °C

14: 74 percent / 2-fluoro-1-methylpyridinium tosylate, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

15: 66 percent / trimethylsilyl trifluoromethanesulfonate / diethyl ether / 7 h / 0 °C

16: 17 percent / Bu₄NF / tetrahydrofuran; acetonitrile / 3 h / Ambient temperature

17: 41 percent / 4 h

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; Celite; (1S)-10-camphorsulfonic acid; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; 1-methyl-2-fluoropyridinium p-toluenesulfonate; methanesulfonyl chloride; 4-methylmorpholine N-oxide; triethylamine; silver carbonate; lithium diisopropyl amide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; acetone; toluene; acetonitrile; tert-butyl alcohol; benzene;