25-<4-benzyloxy-1H-indol-3-yl>-2,2-dimethyl-4,24-dioxo-3-oxa-5,9,13,17,23-pentaazapentacosane-9,13-dicarboxylic acid bis(1,1-dimethylethyl) ester

Base Information

• Chemical Name: 25-<4-benzyloxy-1H-indol-3-yl>-2,2-dimethyl-4,24-dioxo-3-oxa-5,9,13,17,23-pentaazapentacosane-9,13-dicarboxylic acid bis(1,1-dimethylethyl) ester
• CAS No.: 152916-20-6
• Molecular Formula: C₄₆H₇₂N₆O₈
• Molecular Weight: 837.113
• Mol file: 152916-20-6.mol

Synonyms:

Chemical Property of 25-<4-benzyloxy-1H-indol-3-yl>-2,2-dimethyl-4,24-dioxo-3-oxa-5,9,13,17,23-pentaazapentacosane-9,13-dicarboxylic acid bis(1,1-dimethylethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 25-<4-benzyloxy-1H-indol-3-yl>-2,2-dimethyl-4,24-dioxo-3-oxa-5,9,13,17,23-pentaazapentacosane-9,13-dicarboxylic acid bis(1,1-dimethylethyl) ester

There total 14 articles about 25-<4-benzyloxy-1H-indol-3-yl>-2,2-dimethyl-4,24-dioxo-3-oxa-5,9,13,17,23-pentaazapentacosane-9,13-dicarboxylic acid bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-Nitrophenyl <(4-Benzyloxy)-1H-indol-3-yl>acetate (144923-56-8) + 22-amino-2,2-dimethyl-4-oxo-3-oxa-5,9,13,17-tetraaza-docosane-5,9-dicarboxylic acid bis(1,1-dimethylethyl) ester (152916-19-3) → 25-<4-benzyloxy-1H-indol-3-yl>-2,2-dimethyl-4,24-dioxo-3-oxa-5,9,13,17,23-pentaazapentacosane-9,13-dicarboxylic acid bis(1,1-dimethylethyl) ester (152916-20-6)

Guidance literature:

In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81803-2

Reference yield:

1H-indol-4-ol (2380-94-1) → 25-<4-benzyloxy-1H-indol-3-yl>-2,2-dimethyl-4,24-dioxo-3-oxa-5,9,13,17,23-pentaazapentacosane-9,13-dicarboxylic acid bis(1,1-dimethylethyl) ester (152916-20-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 95 percent / K₂CO₃ / acetone / 20 h / Ambient temperature

2: 90 percent / H₂O; acetic acid

4: H₂O

5: 80 percent / KOH, EtOH, H₂O / Heating

6: 100 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 1 h / Ambient temperature

7: 80 percent / dimethylformamide / 1 h / Ambient temperature

With potassium hydroxide; ethanol; water; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0040-4020(01)81803-2

Reference yield:

N-(5-bromopentyl)phthalimide (954-81-4) → 25-<4-benzyloxy-1H-indol-3-yl>-2,2-dimethyl-4,24-dioxo-3-oxa-5,9,13,17,23-pentaazapentacosane-9,13-dicarboxylic acid bis(1,1-dimethylethyl) ester (152916-20-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / KF-celite / acetonitrile / 22 h / 60 °C

2: 96 percent / hydrazine hydrate / methanol / 1 h / 60 °C

3: 80 percent / dimethylformamide / 1 h / Ambient temperature

With potassium fluoride; hydrazine hydrate; In methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4020(01)81803-2

upstream raw materials:

4-Nitrophenyl <(4-Benzyloxy)-1H-indol-3-yl>acetate

22-amino-2,2-dimethyl-4-oxo-3-oxa-5,9,13,17-tetraaza-docosane-5,9-dicarboxylic acid bis(1,1-dimethylethyl) ester

1H-indol-4-ol

N-(5-bromopentyl)phthalimide

Downstream raw materials:

N-(5-{3-[3-(3-Amino-propylamino)-propylamino]-propylamino}-pentyl)-2-(4-benzyloxy-1H-indol-3-yl)-acetamide