Thiocarbonic acid O-{9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-butylsulfanylcarbonylamino-9H-purin-6-yl} ester S-butyl ester

Base Information

Chemical Name:Thiocarbonic acid O-{9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-butylsulfanylcarbonylamino-9H-purin-6-yl} ester S-butyl ester
CAS No.:116135-05-8
Molecular Formula:C₄₆H₅₅N₅O₁₀S₂
Molecular Weight:902.102
Hs Code.:

Thiocarbonic acid O-{9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-butylsulfanylcarbonylamino-9H-purin-6-yl} ester S-butyl ester

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Chemical Property of Thiocarbonic acid O-{9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-butylsulfanylcarbonylamino-9H-purin-6-yl} ester S-butyl ester

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Technology Process of Thiocarbonic acid O-{9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-butylsulfanylcarbonylamino-9H-purin-6-yl} ester S-butyl ester

There total 7 articles about Thiocarbonic acid O-{9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-butylsulfanylcarbonylamino-9H-purin-6-yl} ester S-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 116135-05-8
Thiocarbonic acid O-{9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-butylsulfanylcarbonylamino-9H-purin-6-yl} ester S-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TsOH*H₂O / dioxane / 3 h

2: tri-1-butylammonium hydrogen fluoride

3: pyridine

With pyridine; tri-n-butylamine hydrofluoride; toluene-4-sulfonic acid; In 1,4-dioxane;
DOI:10.1016/S0040-4039(00)96821-7

Reference yield:

: 13889-94-6
butyl chlorothioformate

: 116135-05-8
Thiocarbonic acid O-{9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-butylsulfanylcarbonylamino-9H-purin-6-yl} ester S-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) TMSCl, pyridine; 2.) iPr₂NEt / 1.) 1 h; 2.) 24 h, r.t.

2: 80 percent / iPr₂NEt, pyridine

3: TsOH*H₂O / dioxane / 3 h

4: tri-1-butylammonium hydrogen fluoride

5: pyridine

With pyridine; chloro-trimethyl-silane; tri-n-butylamine hydrofluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1016/S0040-4039(00)96821-7

Reference yield:

: 116113-42-9
Thiocarbonic acid S-butyl ester O-[2-butylsulfanylcarbonylamino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yl] ester

: 116135-05-8
Thiocarbonic acid O-{9-[(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2-butylsulfanylcarbonylamino-9H-purin-6-yl} ester S-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / iPr₂NEt, pyridine

2: TsOH*H₂O / dioxane / 3 h

3: tri-1-butylammonium hydrogen fluoride

4: pyridine

With pyridine; tri-n-butylamine hydrofluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1016/S0040-4039(00)96821-7