Technology Process of N-{3-[4-((S)-2-amino-3-phenylpropylamino)-2-pyridin-4-ylpyrido[3,4-d]pyrimidin-8-yl]phenyl}methanesulfonamide
There total 3 articles about N-{3-[4-((S)-2-amino-3-phenylpropylamino)-2-pyridin-4-ylpyrido[3,4-d]pyrimidin-8-yl]phenyl}methanesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine; dmap / N,N-dimethyl acetamide / 1 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium phosphate / N,N-dimethyl acetamide; water / 0.17 h / 150 °C / Microwave irradiation
2.2: 3 h
With
dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine;
In
N,N-dimethyl acetamide; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: caesium carbonate / methanol; water / 20 °C
2.1: 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine; dmap / N,N-dimethyl acetamide / 1 h / 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0); potassium phosphate / N,N-dimethyl acetamide; water / 0.17 h / 150 °C / Microwave irradiation
3.2: 3 h
With
dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); 2,4,6-triisopropylphenylsulfonyl chloride; caesium carbonate; triethylamine;
In
methanol; N,N-dimethyl acetamide; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / diethyl ether / 4 h / Reflux
2.1: caesium carbonate / methanol; water / 20 °C
3.1: 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine; dmap / N,N-dimethyl acetamide / 1 h / 20 °C
4.1: tetrakis(triphenylphosphine) palladium(0); potassium phosphate / N,N-dimethyl acetamide; water / 0.17 h / 150 °C / Microwave irradiation
4.2: 3 h
With
dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); 2,4,6-triisopropylphenylsulfonyl chloride; potassium carbonate; caesium carbonate; triethylamine;
In
methanol; diethyl ether; N,N-dimethyl acetamide; water;