Technology Process of Pleurotin
There total 6 articles about Pleurotin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
manganese(IV) oxide;
In
dichloromethane;
for 48h;
Ambient temperature;
DOI:10.1021/ja00201a035
-
-
112946-40-4
rel-(3S,4S,4aS,7R,7aR,12bS,12cR)-2,3,4,4a,5,6,7,7a,8,12b-Decahydro-7-hydroxy-9,12-dimethoxy-3-methyl-12cH-4,12c-ethanoanthra<9,1-bc>oxepin
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) (COCl2)2, DMSO, 2.) Et3N / 1.) CH2Cl2, 50 min, 2.) 60 min
2: 1.) t-BuOK / 1.) DME, 8 min
3: 93 percent / i-Bu2AlH / toluene / 1.65 h
4: 62 percent / Ag2O, aq. NaOH / 23 h / 80 - 84 °C
5: 89 percent / ceric ammonium nitrate / acetonitrile; diethyl ether; H2O / 0.5 h
6: 32 percent / active MnO2 / CH2Cl2 / 48 h / Ambient temperature
With
manganese(IV) oxide; sodium hydroxide; ammonium cerium(IV) nitrate; (COCl2)2; potassium tert-butylate; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; silver(l) oxide;
In
diethyl ether; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/ja00201a035
-
-
112946-41-5
rel-(3S,4S,4aS,7aR,12bS,12cR)-2,3,4,4a,5,6,7,7a,8,12b-Decahydro-9,12-dimethoxy-3-methyl-7-oxo-12cH-4,12c-ethanoanthra<9,1-bc>oxepin
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) t-BuOK / 1.) DME, 8 min
2: 93 percent / i-Bu2AlH / toluene / 1.65 h
3: 62 percent / Ag2O, aq. NaOH / 23 h / 80 - 84 °C
4: 89 percent / ceric ammonium nitrate / acetonitrile; diethyl ether; H2O / 0.5 h
5: 32 percent / active MnO2 / CH2Cl2 / 48 h / Ambient temperature
With
manganese(IV) oxide; sodium hydroxide; ammonium cerium(IV) nitrate; potassium tert-butylate; diisobutylaluminium hydride; silver(l) oxide;
In
diethyl ether; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/ja00201a035