1-(Cyclohexyloxycarbonyloxy)ethyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonyl-5-methylimidazo[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate

Base Information

• Chemical Name: 1-(Cyclohexyloxycarbonyloxy)ethyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonyl-5-methylimidazo[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate
• CAS No.: 258836-82-7
• Molecular Formula: C₂₆H₃₃N₃O₉S₂
• Molecular Weight: 595.695

Synonyms:

Chemical Property of 1-(Cyclohexyloxycarbonyloxy)ethyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonyl-5-methylimidazo[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(Cyclohexyloxycarbonyloxy)ethyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonyl-5-methylimidazo[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate

There total 5 articles about 1-(Cyclohexyloxycarbonyloxy)ethyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonyl-5-methylimidazo[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonyl-5-methylimidazo[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate (258835-65-3) + cyclohexyl (1-iodoethyl)carbonate (95789-69-8,102672-57-1) → 1-(Cyclohexyloxycarbonyloxy)ethyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonyl-5-methylimidazo[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate (258836-82-7)

Guidance literature:

Reference yield:

4-Nitrobenzyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-(5-methyl-7-methylthioimidazo-[5,1-b]thiazol-2-yl)-1-carbapen-2-em-3-carboxylate (258840-27-6) → 1-(Cyclohexyloxycarbonyloxy)ethyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonyl-5-methylimidazo[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate (258836-82-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; water

In tetrahydrofuran; water;

Reference yield:

5-Methyl-7-methylthio-2-(tri-n-butylstannyl)imidazo[5,1-b]thiazole (258839-11-1) → 1-(Cyclohexyloxycarbonyloxy)ethyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonyl-5-methylimidazo[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate (258836-82-7)

Guidance literature:

Multi-step reaction with 4 steps

2: tetrahydrofuran; water

In tetrahydrofuran; water;

upstream raw materials:

sodium(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-2-(7-methanesulfonyl-5-methylimidazo[5,1-b]thiazol-2-yl)-1-methyl-1-carbapen-2-em-3-carboxylate

cyclohexyl (1-iodoethyl)carbonate

5-Methyl-7-methylthio-2-(tri-n-butylstannyl)imidazo[5,1-b]thiazole

4-Nitrobenzyl(1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-(5-methyl-7-methylthioimidazo-[5,1-b]thiazol-2-yl)-1-carbapen-2-em-3-carboxylate

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