(1S)-2-(3-Chlorophenyl)-1-methyl-2-oxoethyl 1,1,1-trifluoromethanesulfonate

Base Information

Chemical Name:(1S)-2-(3-Chlorophenyl)-1-methyl-2-oxoethyl 1,1,1-trifluoromethanesulfonate
CAS No.:291275-47-3
Molecular Formula:C₁₀H₈ClF₃O₄S
Molecular Weight:316.685
Hs Code.:
DSSTox Substance ID:DTXSID501143723

Synonyms:DTXSID501143723;(1S)-2-(3-Chlorophenyl)-1-methyl-2-oxoethyl 1,1,1-trifluoromethanesulfonate;291275-47-3

Suppliers and Price of (1S)-2-(3-Chlorophenyl)-1-methyl-2-oxoethyl 1,1,1-trifluoromethanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (1S)-2-(3-Chlorophenyl)-1-methyl-2-oxoethyl 1,1,1-trifluoromethanesulfonate

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:315.9783921
Heavy Atom Count:19
Complexity:429

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(=O)C1=CC(=CC=C1)Cl)OS(=O)(=O)C(F)(F)F
Isomeric SMILES:C[C@@H](C(=O)C1=CC(=CC=C1)Cl)OS(=O)(=O)C(F)(F)F

Technology Process of (1S)-2-(3-Chlorophenyl)-1-methyl-2-oxoethyl 1,1,1-trifluoromethanesulfonate

There total 3 articles about (1S)-2-(3-Chlorophenyl)-1-methyl-2-oxoethyl 1,1,1-trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 287477-53-6
(S)-1-(3-chlorophenyl)-2-hydroxypropan-1-one

: 291275-47-3
Trifluoro-methanesulfonic acid (S)-2-(3-chloro-phenyl)-1-methyl-2-oxo-ethyl ester

Guidance literature:: With lutidine; In dichloromethane; at -40 ℃;
DOI:10.1016/S0957-4166(00)00349-9

Reference yield:

: 34841-35-5
3'-chloro-propiophenone

: 291275-47-3
Trifluoro-methanesulfonic acid (S)-2-(3-chloro-phenyl)-1-methyl-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 °C

2.1: 82 percent / AD-mix-α; H2O / 2-methyl-propan-2-ol

3.1: lutidine / CH₂Cl₂ / -40 °C

With AD-mix-α; lutidine; water; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 1.1: deprotonation / 1.2: silylation / 2.1: Sharpless's asymmetric dihydroxylation / 3.1: triflation;
DOI:10.1016/S0957-4166(00)00349-9

Reference yield:

: 291275-45-1
(Z)-tert-butyl-[1-(3-chlorophenyl)prop-1-enyloxy]dimethylsilane

: 291275-47-3
Trifluoro-methanesulfonic acid (S)-2-(3-chloro-phenyl)-1-methyl-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / AD-mix-α; H2O / 2-methyl-propan-2-ol

2: lutidine / CH₂Cl₂ / -40 °C

With AD-mix-α; lutidine; water; In dichloromethane; tert-butyl alcohol; 1: Sharpless's asymmetric dihydroxylation / 2: triflation;
DOI:10.1016/S0957-4166(00)00349-9