Technology Process of racemic 5(R)-1-aza-4(R)-carboxy-6(R)-hydroxy-4(R)-(phenylseleno)bicyclo<3.3.0>octane lactone
There total 30 articles about racemic 5(R)-1-aza-4(R)-carboxy-6(R)-hydroxy-4(R)-(phenylseleno)bicyclo<3.3.0>octane lactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
calcium carbonate; mercury dichloride;
In
water; acetonitrile;
for 0.5h;
Ambient temperature;
DOI:10.1021/jo00223a002
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 97 percent / H2 / PtO2 / methanol / 1.5 h / 760 Torr / Ambient temperature
2: 75 percent / EtONa, 3-A molecular sieve / ethanol / 2.5 h / Heating
3: 1.) LDA / 1.) THF, -70 deg C, 1.5 h, 2.) a) THF, -70 deg C, 1 h, b) -40 deg C, 1.5 h
With
3 A molecular sieve; hydrogen; sodium ethanolate; lithium diisopropyl amide;
platinum(IV) oxide;
In
methanol; ethanol;
DOI:10.1021/jo00223a002
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 82 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
2: 71 percent / aq. HCl, HgCl2, trifluoroacetic acid / 8 h / Heating
3: 72 percent / trifluoroacetic anhydride, Me2SO / CH2Cl2 / 1 h / -65 °C
4: 97 percent / H2 / PtO2 / methanol / 1.5 h / 760 Torr / Ambient temperature
5: 75 percent / EtONa, 3-A molecular sieve / ethanol / 2.5 h / Heating
6: 1.) LDA / 1.) THF, -70 deg C, 1.5 h, 2.) a) THF, -70 deg C, 1 h, b) -40 deg C, 1.5 h
With
hydrogenchloride; lithium aluminium tetrahydride; 3 A molecular sieve; hydrogen; sodium ethanolate; dimethyl sulfoxide; trifluoroacetic acid; trifluoroacetic anhydride; mercury dichloride; lithium diisopropyl amide;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jo00223a002
