{(2R,3R,4S,5R)-2-[6-[2-(4-Nitro-phenyl)-ethoxy]-2-(trimethylsilanyl-amino)-purin-9-yl]-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-3-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Base Information

Chemical Name:{(2R,3R,4S,5R)-2-[6-[2-(4-Nitro-phenyl)-ethoxy]-2-(trimethylsilanyl-amino)-purin-9-yl]-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-3-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester
CAS No.:213487-34-4
Molecular Formula:C₃₆H₅₂N₈O₁₀Si₃
Molecular Weight:841.113
Hs Code.:

{(2R,3R,4S,5R)-2-[6-[2-(4-Nitro-phenyl)-ethoxy]-2-(trimethylsilanyl-amino)-purin-9-yl]-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-3-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

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Chemical Property of {(2R,3R,4S,5R)-2-[6-[2-(4-Nitro-phenyl)-ethoxy]-2-(trimethylsilanyl-amino)-purin-9-yl]-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-3-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

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Technology Process of {(2R,3R,4S,5R)-2-[6-[2-(4-Nitro-phenyl)-ethoxy]-2-(trimethylsilanyl-amino)-purin-9-yl]-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-3-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

There total 1 articles about {(2R,3R,4S,5R)-2-[6-[2-(4-Nitro-phenyl)-ethoxy]-2-(trimethylsilanyl-amino)-purin-9-yl]-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-3-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88188-06-1
trimethyl((trifluoromethyl)sulfonyl)silane

: 213902-34-2
O⁶-2-(4-nitrophenyl)ethylguanine

: Carbonic acid (2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester 2-(4-nitro-phenyl)-ethyl ester

: 213487-34-4
{(2R,3R,4S,5R)-2-[6-[2-(4-Nitro-phenyl)-ethoxy]-2-(trimethylsilanyl-amino)-purin-9-yl]-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-3-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: With benzenesulfonamide; 1,1,1,3,3,3-hexamethyl-disilazane; Yield given. Multistep reaction; 1.) CH₃CN, reflux, 1 h, 2.) CH₃CN, reflux, 15 h;
DOI:10.1002/hlca.19980810556

Reference yield:

: 213487-34-4
{(2R,3R,4S,5R)-2-[6-[2-(4-Nitro-phenyl)-ethoxy]-2-(trimethylsilanyl-amino)-purin-9-yl]-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-3-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

: 213487-35-5
((2R,3R,4S,5R)-2-{2-Amino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl)-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: With ammonium fluoride; silica gel; In methanol; for 0.0333333h; Yield given;
DOI:10.1002/hlca.19980810556

Reference yield:

: 213487-34-4
{(2R,3R,4S,5R)-2-[6-[2-(4-Nitro-phenyl)-ethoxy]-2-(trimethylsilanyl-amino)-purin-9-yl]-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-3-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

: 213487-39-9
{9-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NH₄F, silica gel / methanol / 0.03 h

2: 73 percent / pyridine

3: 70 percent / pyridine, molecular sieve / 0 deg C, 30 min; RT, 3 d

4: 78 percent / Bu₄NF*3H₂O / tetrahydrofuran; acetic acid / 72 h

5: 53 percent / pyridine, molecular sieve (4 Angstroem)

With pyridine; ammonium fluoride; molecular sieve; 4 A molecular sieve; tetrabutyl ammonium fluoride; silica gel; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1002/hlca.19980810556