1-[5-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-benzyl]-cyclohexanol

Base Information

Chemical Name:1-[5-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-benzyl]-cyclohexanol
CAS No.:124609-22-9
Molecular Formula:C₁₉H₂₇NO₃
Molecular Weight:317.428
Hs Code.:

Synonyms:

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Chemical Property of 1-[5-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-benzyl]-cyclohexanol

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Technology Process of 1-[5-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-benzyl]-cyclohexanol

There total 9 articles about 1-[5-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-benzyl]-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 124609-20-7
2-[2,4-Dimethoxy-3-(7-oxa-bicyclo[4.1.0]hept-1-ylmethyl)-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

: 124609-22-9
1-[5-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-benzyl]-cyclohexanol

: 124609-21-8
3-(1-hydroxycyclohexan-1-yl)methyl-2,4-dimethoxy-1-(4,5-dihydro-4,4-dimethyloxazol-2-yl)benzene

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Yields of byproduct given; Ambient temperature;

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 124609-22-9
1-[5-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-benzyl]-cyclohexanol

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / Amberlyst-15 (H⁺) resin / tetrahydrofuran / 2 h / 0 - 5 °C

2: 1.) BuLi, copper (I) bromide - dimethyl sulphide complex / 1.) hexane, THF, 0 deg C, 1 h, 2.) 1 h

3: 77 percent / silver oxide / ethanol

4: 99 percent / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / tetrahydrofuran / 0.5 h / Ambient temperature

5: 89 percent / thionyl chloride / benzene / 2 h / Ambient temperature

6: 95 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) room temperature, 20 min

7: 25 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

With lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; copper(I) bromide dimethylsulfide complex; benzotriazol-1-ol; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; silver(l) oxide; Amberlyst-15 (H⁺) resin; In tetrahydrofuran; ethanol; dichloromethane; benzene;

Reference yield:

: 4845-04-9
1-cyclohexene-1-methanol

: 124609-22-9
1-[5-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-benzyl]-cyclohexanol

Guidance literature:: Multi-step reaction with 7 steps

1: methyl sulphide, N-bromosuccinimide / CH₂Cl₂ / 1 h / 0 °C

2: 1.) BuLi, copper (I) bromide - dimethyl sulphide complex / 1.) hexane, THF, 0 deg C, 1 h, 2.) 1 h

3: 77 percent / silver oxide / ethanol

4: 99 percent / dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / tetrahydrofuran / 0.5 h / Ambient temperature

5: 89 percent / thionyl chloride / benzene / 2 h / Ambient temperature

6: 95 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) room temperature, 20 min

7: 25 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

With N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; copper(I) bromide dimethylsulfide complex; dimethylsulfide; benzotriazol-1-ol; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; silver(l) oxide; In tetrahydrofuran; ethanol; dichloromethane; benzene;