C₁₉H₁₃F₅N₄

Base Information

Chemical Name:C₁₉H₁₃F₅N₄
CAS No.:1620328-20-2
Molecular Formula:C₁₉H₁₃F₅N₄
Molecular Weight:392.331
Hs Code.:

C<sub>19</sub>H<sub>13</sub>F<sub>5</sub>N<sub>4</sub>

Synonyms:

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Chemical Property of C₁₉H₁₃F₅N₄

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Technology Process of C₁₉H₁₃F₅N₄

There total 13 articles about C₁₉H₁₃F₅N₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1629023-84-2
C₃₈H₂₇F₅N₄

: 1620328-20-2
C₁₉H₁₃F₅N₄

Guidance literature:: With N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/j.bmcl.2014.05.082

Reference yield:

: 1160502-31-7
4-iodo-3-(trifluoromethyl)-1-tritylpyrazolo[5,4-b]pyridine

: 1620328-20-2
C₁₉H₁₃F₅N₄

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 14 h / 105 °C

2: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / tetrahydrofuran; water / 2.5 h / 20 °C

3: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid / dichloromethane / 2 h / 0 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; potassium acetate; trifluoroacetic acid; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling / 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.082

Reference yield:

: 1435-51-4
1,3-dibromo-5-fluorobenzene

: 1620328-20-2
C₁₉H₁₃F₅N₄

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 24 h / 120 °C

2.1: lithium chloride / dimethyl sulfoxide; water / 3 h / 165 °C

3.1: tetrabutylammomium bromide; sodium hydroxide / toluene; water / 16 h / 20 °C

4.1: copper(l) cyanide; TurboGrignard / tetrahydrofuran / 1 h / 0 - 20 °C

5.1: ozone / dichloromethane; methanol / 1 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -20 °C

7.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / tetrahydrofuran; water / 2.5 h / 20 °C

8.1: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid / dichloromethane / 2 h / 0 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; TurboGrignard; diethylamino-sulfur trifluoride; N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; tetrabutylammomium bromide; copper(l) cyanide; sodium hydride; ozone; trifluoroacetic acid; lithium chloride; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; dimethyl sulfoxide; toluene; 2.1: |Krapcho Dealkoxycarbonylation / 7.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.082