Pyrrolidine, 1-butyl-4-(1,1-dimethylethyl)-2-ethyl-, (2R,4S)-rel- (9CI)

Base Information

Chemical Name:Pyrrolidine, 1-butyl-4-(1,1-dimethylethyl)-2-ethyl-, (2R,4S)-rel- (9CI)
CAS No.:351326-02-8
Molecular Formula:C₁₄H₂₉N
Molecular Weight:211.391
Hs Code.:
Mol file:351326-02-8.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrrolidine, 1-butyl-4-(1,1-dimethylethyl)-2-ethyl-, (2R,4S)-rel- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of Pyrrolidine, 1-butyl-4-(1,1-dimethylethyl)-2-ethyl-, (2R,4S)-rel- (9CI)

There total 16 articles about Pyrrolidine, 1-butyl-4-(1,1-dimethylethyl)-2-ethyl-, (2R,4S)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1-Butyl-4-tert-butyl-2-(1-chloroethyl)pyrrolidine

: 351326-02-8
1-Butyl-4-tert-butyl-2-ethylpyrrolidine

Guidance literature:: With boron trifluoride diethyl etherate; tri-n-butyl-tin hydride; In benzene-d6; at 20 ℃; UV-irradiation;

Reference yield:

: 5340-78-3
ethyl 3,3-dimethylbutanoate

: 351326-02-8
1-Butyl-4-tert-butyl-2-ethylpyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: KHMDS / tetrahydrofuran / 0.5 h / 0 °C

1.2: 56 percent / tetrahydrofuran / 16 h / -78 - 20 °C

2.1: 80 percent / LiAlH₄ / diethyl ether / 18 h / 0 - 20 °C

3.1: 83 percent / DIPEA / CH₂Cl₂

4.1: 75 percent / Heating

5.1: 34 percent / NCS / CH₂Cl₂ / 0.5 h / -30 °C

6.1: 93 percent / BF₃*Et₂O; TiCl₃ / CH₂Cl₂ / 0.5 h / -78 °C

7.1: 93 percent / BF₃*Et₂O; Bu₃SnH / benzene-d6 / 20 °C / UV-irradiation

With N-chloro-succinimide; lithium aluminium tetrahydride; titanium(III) chloride; boron trifluoride diethyl etherate; tri-n-butyl-tin hydride; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; benzene-d6;

Reference yield:

: 132621-51-3
2-tert-butyl-4-penten-1-ol

: 351326-02-8
1-Butyl-4-tert-butyl-2-ethylpyrrolidine

Guidance literature:: Multi-step reaction with 10 steps

1.1: 99 percent / TEA; pyridine / CH₂Cl₂ / 18 h / 0 - 20 °C

2.1: 90 percent / aq. OsO₄; NMO / 2-methyl-propan-2-ol; tetrahydrofuran / 1.5 h / 20 °C

3.1: 85 percent / NaIO₄; aq. NaHCO₃ / tetrahydrofuran / 4.5 h / 20 °C

4.1: KHMDS / tetrahydrofuran / 1.5 h / 20 °C

4.2: 80 percent / tetrahydrofuran / 1.5 h / -20 - 20 °C

5.1: 86 percent / TBAF / tetrahydrofuran / 20 °C

6.1: 88 percent / TEA / CH₂Cl₂

7.1: 98 percent / Heating

8.1: 82 percent / NCS / CH₂Cl₂ / 0.5 h / -30 °C

9.1: 100 percent / BF₃*Et₂O; TiCl₃ / CH₂Cl₂ / 0.5 h / -78 °C

10.1: 93 percent / BF₃*Et₂O; Bu₃SnH / benzene-d6 / 20 °C / UV-irradiation

With pyridine; sodium periodate; N-chloro-succinimide; osmium(VIII) oxide; N-methyl-2-indolinone; titanium(III) chloride; TEA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; potassium hexamethylsilazane; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; benzene-d6; tert-butyl alcohol;