Technology Process of {1-[2-(4-tert-butoxy-2-{2-[2-(1-hydroxymethyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-pyrrolidin-1-yl)-1,1-dimethyl-2-oxo-ethylcarbamoyl]-3-carbamoyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
There total 10 articles about {1-[2-(4-tert-butoxy-2-{2-[2-(1-hydroxymethyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-pyrrolidin-1-yl)-1,1-dimethyl-2-oxo-ethylcarbamoyl]-3-carbamoyl-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 92 percent / benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DIPEA / dimethylformamide / 0.67 h
2.1: TFA / CHCl3 / 0.33 h / 20 °C
3.1: benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DMAP / dimethylformamide / 0.17 h
3.2: 444 mg / DIPEA / dimethylformamide / 0.5 h
4.1: NaOH / dioxane; methanol; H2O / 0.07 h
5.1: 330 mg / benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DIPEA / dimethylformamide / 0.67 h
6.1: NaOH / dioxane; methanol; H2O
7.1: benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DMAP / dimethylformamide / 0.17 h
7.2: 120 mg / DIPEA / dimethylformamide / 0.5 h
8.1: NaOH / dioxane; methanol; H2O
9.1: 83 mg / benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DIPEA / dimethylformamide
With
dmap; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 92 percent / benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DIPEA / dimethylformamide / 0.67 h
2.1: TFA / CHCl3 / 0.33 h / 20 °C
3.1: benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DMAP / dimethylformamide / 0.17 h
3.2: 444 mg / DIPEA / dimethylformamide / 0.5 h
4.1: NaOH / dioxane; methanol; H2O / 0.07 h
5.1: 330 mg / benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DIPEA / dimethylformamide / 0.67 h
6.1: NaOH / dioxane; methanol; H2O
7.1: benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DMAP / dimethylformamide / 0.17 h
7.2: 120 mg / DIPEA / dimethylformamide / 0.5 h
8.1: NaOH / dioxane; methanol; H2O
9.1: 83 mg / benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DIPEA / dimethylformamide
With
dmap; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: TFA / CHCl3 / 0.33 h / 20 °C
2.1: benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DMAP / dimethylformamide / 0.17 h
2.2: 444 mg / DIPEA / dimethylformamide / 0.5 h
3.1: NaOH / dioxane; methanol; H2O / 0.07 h
4.1: 330 mg / benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DIPEA / dimethylformamide / 0.67 h
5.1: NaOH / dioxane; methanol; H2O
6.1: benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DMAP / dimethylformamide / 0.17 h
6.2: 120 mg / DIPEA / dimethylformamide / 0.5 h
7.1: NaOH / dioxane; methanol; H2O
8.1: 83 mg / benzotriazol-1-yloxy-tris(Me2N)phosphonium(1+)*PF6(1-); DIPEA / dimethylformamide
With
dmap; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;