4-(2-Dimethylamino-ethyl)-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one; hydrochloride

Base Information

Chemical Name:4-(2-Dimethylamino-ethyl)-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one; hydrochloride
CAS No.:139516-37-3
Molecular Formula:C₂₉H₃₉FN₄O₂*2ClH
Molecular Weight:567.575
Hs Code.:

4-(2-Dimethylamino-ethyl)-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one; hydrochloride

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Chemical Property of 4-(2-Dimethylamino-ethyl)-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one; hydrochloride

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Technology Process of 4-(2-Dimethylamino-ethyl)-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one; hydrochloride

There total 12 articles about 4-(2-Dimethylamino-ethyl)-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1125-78-6
5,6,7,8-Tetrahydro-2-naphthol

: 139516-37-3
4-(2-Dimethylamino-ethyl)-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 24.6 percent / NaNO₃, La(NO₃)3*6H₂O, 6 N HCl / diethyl ether / 20 h / Ambient temperature

2: 98.2 percent / K₂CO₃ / dimethylformamide / 8 h / Ambient temperature

3: 81.1 percent / H₂ / 5percent Pd/C / ethanol

4: 59.3 percent / NEt₃ / dimethylformamide / 1.5 h / 80 °C

5: 1.) NaH / 1.) DMF, 0 deg C 2.) 0 deg C

With hydrogenchloride; sodium nitrate; hydrogen; sodium hydride; potassium carbonate; lanthanum(III) nitrate; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2896

Reference yield:

: 6240-79-5
5,6,7,8-Tetrahydro-3-nitro-2-naphthol

: 139516-37-3
4-(2-Dimethylamino-ethyl)-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 98.2 percent / K₂CO₃ / dimethylformamide / 8 h / Ambient temperature

2: 81.1 percent / H₂ / 5percent Pd/C / ethanol

3: 59.3 percent / NEt₃ / dimethylformamide / 1.5 h / 80 °C

4: 1.) NaH / 1.) DMF, 0 deg C 2.) 0 deg C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2896

Reference yield:

: 112249-84-0
methyl 5-bromo-2-(5,6,7,8-tetrahydro-3-nitro-2-naphthyloxy)valerate

: 139516-37-3
4-(2-Dimethylamino-ethyl)-2-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 81.1 percent / H₂ / 5percent Pd/C / ethanol

2: 59.3 percent / NEt₃ / dimethylformamide / 1.5 h / 80 °C

3: 1.) NaH / 1.) DMF, 0 deg C 2.) 0 deg C

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2896