Methanone, (4-methylphenyl)-2-naphthalenyl-

Base Information

• Chemical Name: Methanone, (4-methylphenyl)-2-naphthalenyl-
• CAS No.: 136935-71-2
• Molecular Formula: C18H14O
• Molecular Weight: 246.309
• DSSTox Substance ID: DTXSID00474984
• Nikkaji Number: J415.987J
• Wikidata: Q82305187
• Mol file: 136935-71-2.mol

Synonyms:Methanone, (4-methylphenyl)-2-naphthalenyl-;136935-71-2;(2-Naphthyl)(p-tolyl) ketone;SCHEMBL15040985;DTXSID00474984;naphthalen-2-yl(p-tolyl)methanone

Chemical Property of Methanone, (4-methylphenyl)-2-naphthalenyl-

Chemical Property:

• PSA: 17.07000
• LogP: 4.37920
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 246.104465066
• Heavy Atom Count: 19
• Complexity: 314

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)C2=CC3=CC=CC=C3C=C2

Technology Process of Methanone, (4-methylphenyl)-2-naphthalenyl-

There total 40 articles about Methanone, (4-methylphenyl)-2-naphthalenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tri(p-tolyl)bismuth (5142-75-6) + 2-naphthaloyl chloride (2243-83-6) → β-naphthyl-4-methylphenyl-ketone (136935-71-2)

Guidance literature:

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 3h;

DOI:10.1016/j.tet.2007.10.047

Reference yield: 94.0%

di(p-tolyl)borinic acid (66117-64-4) + N-methyl-N-tosyl-2-naphthamide → β-naphthyl-4-methylphenyl-ketone (136935-71-2)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; In tetrahydrofuran; at 65 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2018.05.003

Reference yield: 92.0%

naphthalene (91-20-3,71998-51-1,72931-45-4) + 4-methyl-benzoyl chloride (874-60-2) → (4-methylphenyl)(1-naphthyl)methanone (62723-07-3) + β-naphthyl-4-methylphenyl-ketone (136935-71-2)

Guidance literature:

With Zn-triflate loaded in mesoporous SBA-15 silicate; In nitrobenzene; at 140 ℃;

DOI:10.1016/j.apcata.2009.10.021

upstream raw materials:

2-naphthalenecarbonitrile

para-methylphenylmagnesium bromide

naphthalen-2-yl(p–tolyl)methanol

2-naphthalenylmagnesium bromide

Downstream raw materials:

naphthalen-2-yl(p–tolyl)methanol

(4-(bromomethyl)phenyl)naphthalen-2-ylmethanone

2-(p-tolyl)naphthalene

1-(Naphthalen-2-yl-p-tolyl-methyl)-1H-imidazole

Refernces

• 1、 Fieser,Martin. "-". . p. 1443. Retrieved 1936.
• 2、 He, Min,Yu, Xiaoqiang,Wang, Yi,Li, Fei,Bao, Ming. "Self-Assembled 2,3-Dicyanopyrazino Phenanthrene Aggregates as a Visible-Light Photocatalyst". . p. 5016 - 5025. Retrieved 2021/04/12.
• 3、 Dorval, Céline,Dubois, Elodie,Bourne-Branchu, Yann,Gosmini, Corinne,Danoun, Grégory. "Sequential Organozinc Formation and Negishi Cross-Coupling of Amides Catalysed by Cobalt Salt". supporting information. p. 1777 - 1780. Retrieved 2019/02/26.