1-cyclopropylmethyl-cyclobutanecarbaldehyde

Base Information

• Chemical Name: 1-cyclopropylmethyl-cyclobutanecarbaldehyde
• CAS No.: 518346-55-9
• Molecular Formula: C₉H₁₄O
• Molecular Weight: 138.21
• Mol file: 518346-55-9.mol

Synonyms:

Chemical Property of 1-cyclopropylmethyl-cyclobutanecarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclopropylmethyl-cyclobutanecarbaldehyde

There total 3 articles about 1-cyclopropylmethyl-cyclobutanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-cyclopropylmethyl-cyclobutyl)-methanol (433219-80-8) → 1-cyclopropylmethyl-cyclobutanecarbaldehyde (518346-55-9)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 0 ℃; for 1.5h;

DOI:10.1016/S0968-0896(01)00369-8

Reference yield:

Cyclobutanecarboxylic acid (3721-95-7) → 1-cyclopropylmethyl-cyclobutanecarbaldehyde (518346-55-9)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium diisopropylamide / tetrahydrofuran / 12 h / 20 °C

2: LiAlH₄ / diethyl ether / 3.5 h / 20 °C

3: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 1.5 h / -78 - 0 °C

With lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; 3: Swern oxidation;

DOI:10.1016/S0968-0896(01)00369-8

Reference yield:

1-cyclopropylmethyl-cyclobutanecarboxylic acid (518346-54-8) → 1-cyclopropylmethyl-cyclobutanecarbaldehyde (518346-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 3.5 h / 20 °C

2: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 1.5 h / -78 - 0 °C

With lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; 2: Swern oxidation;

DOI:10.1016/S0968-0896(01)00369-8

upstream raw materials:

(1-cyclopropylmethyl-cyclobutyl)-methanol

Cyclobutanecarboxylic acid

1-cyclopropylmethyl-cyclobutanecarboxylic acid

Downstream raw materials:

4-(2-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-4-(tert-butyl-dimethyl-silanyloxy)-4-(1-cyclopropylmethyl-cyclobutyl)-but-1-enyl]-5-oxo-cyclopentyl}-ethyl)-benzoic acid methyl ester