ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-methoxycarbonylthiopropionate

Base Information

• Chemical Name: ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-methoxycarbonylthiopropionate
• CAS No.: 100281-48-9
• Molecular Formula: C₂₀H₁₉ClO₆S
• Molecular Weight: 422.886
• Mol file: 100281-48-9.mol

Synonyms:

Chemical Property of ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-methoxycarbonylthiopropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-methoxycarbonylthiopropionate

There total 4 articles about ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-methoxycarbonylthiopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.8%

ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-mercaptopropionate (88107-22-6) + methyl chloroformate (79-22-1) → ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-methoxycarbonylthiopropionate (100281-48-9)

Guidance literature:

With pyridine; In diethyl ether; for 3h; Ambient temperature;

DOI:10.1248/cpb.33.2386

Reference yield:

ethyl 3-<4-(4-chlorophenoxy)benzoyl>acrylate (88113-23-9) → ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-methoxycarbonylthiopropionate (100281-48-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 93.2 percent / CH₂Cl₂

2: 76.1 percent / cc. H₂SO₄, H₂O, AcOH

3: 50.8 percent / pyridine / diethyl ether / 3 h / Ambient temperature

With pyridine; sulfuric acid; water; acetic acid; In diethyl ether; dichloromethane;

DOI:10.1248/cpb.33.2386

Reference yield:

(trans)-3-<4-(4-chlorophenoxy)benzoyl>acrylic acid (73980-30-0) → ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-methoxycarbonylthiopropionate (100281-48-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 92.3 percent / K₂CO₃ / dimethylformamide

2: 93.2 percent / CH₂Cl₂

3: 76.1 percent / cc. H₂SO₄, H₂O, AcOH

4: 50.8 percent / pyridine / diethyl ether / 3 h / Ambient temperature

With pyridine; sulfuric acid; water; potassium carbonate; acetic acid; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.2386

upstream raw materials:

ethyl 3-<4-(4-chlorophenoxy)benzoyl>-2-mercaptopropionate

methyl chloroformate

ethyl 3-<4-(4-chlorophenoxy)benzoyl>acrylate

(trans)-3-<4-(4-chlorophenoxy)benzoyl>acrylic acid

Refernces