Technology Process of Z-Gln-Ile-Cys(Bzl)-Leu-OMe
There total 1 articles about Z-Gln-Ile-Cys(Bzl)-Leu-OMe which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: anisole, 25 percent HBr/AcOH / 0.5 h / Ambient temperature
2: 1.) Et3N, ethylchloroformate / 1.) DMF, -10 deg C; 2.) DMF, buffer Et3N (pH 8), 0 deg C, 5 h
With
hydrogen bromide; chloroformic acid ethyl ester; acetic acid; methoxybenzene; triethylamine;
DOI:10.1248/cpb.28.2105
- Guidance literature:
-
Multi-step reaction with 4 steps
1: anisole, 25 percent HBr/AcOH / acetic acid
2: 1.) Et3N, ethylchloroformate / 1.) -10 deg C; 2.) DMF, buffer Et3N (pH 8), 5 h
3: anisole, 25 percent HBr/AcOH / acetic acid
4: 1.) Et3N, ethyl chloroformate / 1.) DMF, -10 deg C; 2.) DMF, buffer Et3N (pH 8), 5 h
With
hydrogen bromide; chloroformic acid ethyl ester; acetic acid; methoxybenzene; triethylamine;
In
acetic acid;
DOI:10.1248/cpb.28.2105
- Guidance literature:
-
Multi-step reaction with 5 steps
1: anisole, 25 percent HBr/AcOH / acetic acid
2: 1.) Et3N, ethylchloroformate / 1.) -10 deg C; 2.) DMF, buffer Et3N (pH 8), 5 h
3: anisole, 25 percent HBr/AcOH / acetic acid
4: 1.) Et3N, ethyl chloroformate / 1.) DMF, -10 deg C; 2.) DMF, buffer Et3N (pH 8), 5 h
5: 12 percent / hydrazine hydrate / dimethylformamide; butan-1-ol / 96 h / Ambient temperature
With
hydrogen bromide; chloroformic acid ethyl ester; hydrazine hydrate; acetic acid; methoxybenzene; triethylamine;
In
acetic acid; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1248/cpb.28.2105
