5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methylimidazolidine-2,4-dione

Base Information

• Chemical Name: 5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methylimidazolidine-2,4-dione
• CAS No.: 301301-43-9
• Molecular Formula: C₁₂H₁₂N₂O₄
• Molecular Weight: 248.238
• European Community (EC) Number: 820-277-9
• Mol file: 301301-43-9.mol

Synonyms:5-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methylimidazolidine-2,4-dione;301301-43-9;5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methylimidazolidine-2,4-dione;Oprea1_358367;SCHEMBL103407;YPNDMRZCZYOGIW-UHFFFAOYSA-N;BMA30143;AKOS000263229;AKOS017268779;CS-0220692;EN300-07298;SR-01000012715;SR-01000012715-1;Z56759204;F1441-0214;5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-2,4-imidazolidinedione

Chemical Property of 5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methylimidazolidine-2,4-dione

Chemical Property:

• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 248.07970687
• Heavy Atom Count: 18
• Complexity: 386

Purity/Quality:

99% ^*data from raw suppliers

5-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-5-METHYLIMIDAZOLIDINE-2,4-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1(C(=O)NC(=O)N1)C2=CC3=C(C=C2)OCCO3

Technology Process of 5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methylimidazolidine-2,4-dione

There total 3 articles about 5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzo-1,4-dioxane (493-09-4) → 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methylimidazolidine-2,4-dione (301301-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride; carbonic acid dimethyl ester / 20 °C

2: water; ethanol / 70 °C

With aluminum (III) chloride; carbonic acid dimethyl ester; In ethanol; water; 1: |Friedel-Crafts Acylation / 2: |Bucherer-Bergs Reaction;

DOI:10.1016/j.bmcl.2015.04.080

Reference yield:

ammonium carbonate + sodium cyanide (773837-37-9) + 1,4-benzodioxan-6-yl methyl ketone (2879-20-1) → 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methylimidazolidine-2,4-dione (301301-43-9)

Guidance literature:

In ethanol; water; at 70 ℃;

DOI:10.1016/j.bmcl.2015.04.080

Reference yield:

→ 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methylimidazolidine-2,4-dione (301301-43-9)

Guidance literature:

upstream raw materials:

benzo-1,4-dioxane

sodium cyanide

1,4-benzodioxan-6-yl methyl ketone

Downstream raw materials:

5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)-2,6-di-n-propylphenoxy)butyl)-5-methylimidazolidine-2,4-dione

5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)-2-n-propylphenoxy)butyl)-5-methylimidazolidine-2,4-dione

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