Technology Process of tert-butyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]amino}phenoxy)acetate
There total 4 articles about tert-butyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]amino}phenoxy)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 82 percent / K2CO3 / dimethylformamide / 3 h / 70 °C
2: H2 / 5percent Pd/C / methanol; ethyl acetate / 0.75 h / 760 Torr
3: EDC*HCl, DMAP / CH2Cl2 / Ambient temperature
With
dmap; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.434
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 82 percent / K2CO3 / dimethylformamide / 3 h / 70 °C
2: H2 / 5percent Pd/C / methanol; ethyl acetate / 0.75 h / 760 Torr
3: EDC*HCl, DMAP / CH2Cl2 / Ambient temperature
With
dmap; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.434
- Guidance literature:
-
Multi-step reaction with 2 steps
1: H2 / 5percent Pd/C / methanol; ethyl acetate / 0.75 h / 760 Torr
2: EDC*HCl, DMAP / CH2Cl2 / Ambient temperature
With
dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.46.434
