[4-(tert-butoxycarbonylamino-imino-methyl)-benzyl]-{4-[(tert-butyl-dimethyl-silanyloxy)-m-tolyl-methyl]-pyridin-2-yl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:[4-(tert-butoxycarbonylamino-imino-methyl)-benzyl]-{4-[(tert-butyl-dimethyl-silanyloxy)-m-tolyl-methyl]-pyridin-2-yl}-carbamic acid tert-butyl ester
CAS No.:950918-65-7
Molecular Formula:C₃₇H₅₂N₄O₅Si
Molecular Weight:660.929
Hs Code.:

[4-(tert-butoxycarbonylamino-imino-methyl)-benzyl]-{4-[(tert-butyl-dimethyl-silanyloxy)-m-tolyl-methyl]-pyridin-2-yl}-carbamic acid tert-butyl ester

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Chemical Property of [4-(tert-butoxycarbonylamino-imino-methyl)-benzyl]-{4-[(tert-butyl-dimethyl-silanyloxy)-m-tolyl-methyl]-pyridin-2-yl}-carbamic acid tert-butyl ester

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Technology Process of [4-(tert-butoxycarbonylamino-imino-methyl)-benzyl]-{4-[(tert-butyl-dimethyl-silanyloxy)-m-tolyl-methyl]-pyridin-2-yl}-carbamic acid tert-butyl ester

There total 9 articles about [4-(tert-butoxycarbonylamino-imino-methyl)-benzyl]-{4-[(tert-butyl-dimethyl-silanyloxy)-m-tolyl-methyl]-pyridin-2-yl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 950918-56-6
(2-amino-pyridin-4-yl)-m-tolyl-methanone

: 950918-65-7
[4-(tert-butoxycarbonylamino-imino-methyl)-benzyl]-{4-[(tert-butyl-dimethyl-silanyloxy)-m-tolyl-methyl]-pyridin-2-yl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / toluene / 10 h / Heating

1.2: sodium triacetoxyborohydride / CH₂Cl₂ / 3 h / 20 °C

2.1: DMAP / CH₂Cl₂ / 24 h

3.1: sodium borohydride / methanol / 0.17 h / 20 °C

4.1: 2,4,6-trimethylpyridine / CH₂Cl₂ / 0.67 h / 20 °C

5.1: NH₂OH*HCl; diisopropylethylamine / ethanol / 1.5 h / Heating

6.1: acetic acid / 0.5 h / 20 °C

7.1: H₂ / Pd/C / methanol / 0.5 h / 760.05 Torr

8.1: CH₂Cl₂ / 0.08 h

With 2,4,6-trimethyl-pyridine; dmap; sodium tetrahydroborate; hydroxylamine hydrochloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid; toluene;
DOI:10.1039/b705344d

Reference yield:

: 950918-59-9
(4-cyano-benzyl)-[4-(3-methyl-benzoyl)-pyridin-2-yl]-carbamic acid tert-butyl ester

: 950918-65-7
[4-(tert-butoxycarbonylamino-imino-methyl)-benzyl]-{4-[(tert-butyl-dimethyl-silanyloxy)-m-tolyl-methyl]-pyridin-2-yl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sodium borohydride / methanol / 0.17 h / 20 °C

2: 2,4,6-trimethylpyridine / CH₂Cl₂ / 0.67 h / 20 °C

3: NH₂OH*HCl; diisopropylethylamine / ethanol / 1.5 h / Heating

4: acetic acid / 0.5 h / 20 °C

5: H₂ / Pd/C / methanol / 0.5 h / 760.05 Torr

6: CH₂Cl₂ / 0.08 h

With 2,4,6-trimethyl-pyridine; sodium tetrahydroborate; hydroxylamine hydrochloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid;
DOI:10.1039/b705344d

Reference yield:

: C₃₂H₄₄N₄O₄Si

: 950918-65-7
[4-(tert-butoxycarbonylamino-imino-methyl)-benzyl]-{4-[(tert-butyl-dimethyl-silanyloxy)-m-tolyl-methyl]-pyridin-2-yl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 0.5 h / 20 °C

2: H₂ / Pd/C / methanol / 0.5 h / 760.05 Torr

3: CH₂Cl₂ / 0.08 h

With hydrogen; palladium on activated charcoal; In methanol; dichloromethane; acetic acid;
DOI:10.1039/b705344d