CarbaMic acid, N-[[4-[[(4-aMino[1,1'-biphenyl]-3-yl)aMino]carbonyl]phenyl]Methyl]-, Methyl ester

Base Information

• Chemical Name: CarbaMic acid, N-[[4-[[(4-aMino[1,1'-biphenyl]-3-yl)aMino]carbonyl]phenyl]Methyl]-, Methyl ester
• CAS No.: 1013330-79-4
• Molecular Formula: C₂₂H₂₁N₃O₃
• Molecular Weight: 375.427
• Mol file: 1013330-79-4.mol

Synonyms:

Chemical Property of CarbaMic acid, N-[[4-[[(4-aMino[1,1'-biphenyl]-3-yl)aMino]carbonyl]phenyl]Methyl]-, Methyl ester

Chemical Property:

• Melting Point: 172-174°C
• Boiling Point: 532.2±50.0 °C(Predicted)
• PKA: 11.65±0.46(Predicted)
• Density: 1.261±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N-[[4-[[(4-Amino[1,1''-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester is a biaryl benzamides that exhibit inhibitory selectivity over class II Histone Deacetylase (HDACs) and as well as class I HDACs. N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester was deteremined to be a potent and selective inhibitor of HDAC with reduced off-tar get activity and tumor growth inhibition activity.

Technology Process of CarbaMic acid, N-[[4-[[(4-aMino[1,1'-biphenyl]-3-yl)aMino]carbonyl]phenyl]Methyl]-, Methyl ester

There total 2 articles about CarbaMic acid, N-[[4-[[(4-aMino[1,1'-biphenyl]-3-yl)aMino]carbonyl]phenyl]Methyl]-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl [3-({[4-({[(methyloxy)carbonyl]amino}methyl)phenyl]carbonyl}amino)biphenyl-4-yl]carbamate (1013330-69-2) → methyl [(4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}phenyl)methyl]carbamate (1013330-79-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2007.11.047

Reference yield:

→ methyl [(4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}phenyl)methyl]carbamate (1013330-79-4)

Guidance literature:

upstream raw materials:

1,1-dimethylethyl [3-({[4-({[(methyloxy)carbonyl]amino}methyl)phenyl]carbonyl}amino)biphenyl-4-yl]carbamate

Refernces

• 1、 -. "4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS". Page/Page column 65. . Retrieved 2009/03/07.