6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic acid {1-benzothiazol-2-ylmethyl-2-[4-(2-fluoro-ethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide

Base Information

• Chemical Name: 6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic acid {1-benzothiazol-2-ylmethyl-2-[4-(2-fluoro-ethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
• CAS No.: 184043-78-5
• Molecular Formula: C₄₆H₅₇FN₄O₄S₂Si
• Molecular Weight: 841.199

Synonyms:

Chemical Property of 6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic acid {1-benzothiazol-2-ylmethyl-2-[4-(2-fluoro-ethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic acid {1-benzothiazol-2-ylmethyl-2-[4-(2-fluoro-ethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide

There total 7 articles about 6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic acid {1-benzothiazol-2-ylmethyl-2-[4-(2-fluoro-ethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethyl-malonyl monochloride (26576-31-8) → 6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic acid {1-benzothiazol-2-ylmethyl-2-[4-(2-fluoro-ethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide (184043-78-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 20 °C

2: P₂O₅; CH₃SO₃H / 70 °C

3: AlCl₃; LAH / tetrahydrofuran; diethyl ether / Heating

4: imidazole

5: SO₃; pyridine / Heating

6: POCl₃; pyridine / acetonitrile / 20 °C / microwave irradiation

7: DIPEA / CH₂Cl₂

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; aluminium trichloride; methanesulfonic acid; sulfur trioxide; phosphorus pentoxide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; 1: Acylation / 2: Cyclization / 3: Reduction / 4: silylation / 5: sulphonation / 6: Chlorination / 7: sulfonylation;

DOI:10.1016/S0960-894X(00)00283-3

Reference yield:

2,2-dimethylmalonic acid (595-46-0) → 6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic acid {1-benzothiazol-2-ylmethyl-2-[4-(2-fluoro-ethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide (184043-78-5)

Guidance literature:

Multi-step reaction with 8 steps

1: SOCl₂ / tetrahydrofuran / Heating

2: 20 °C

3: P₂O₅; CH₃SO₃H / 70 °C

4: AlCl₃; LAH / tetrahydrofuran; diethyl ether / Heating

5: imidazole

6: SO₃; pyridine / Heating

7: POCl₃; pyridine / acetonitrile / 20 °C / microwave irradiation

8: DIPEA / CH₂Cl₂

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; aluminium trichloride; thionyl chloride; methanesulfonic acid; sulfur trioxide; phosphorus pentoxide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; 1: Chlorination / 2: Acylation / 3: Cyclization / 4: Reduction / 5: silylation / 6: sulphonation / 7: Chlorination / 8: sulfonylation;

DOI:10.1016/S0960-894X(00)00283-3

Reference yield:

2-(3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl)-ethanol (184041-91-6) → 6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic acid {1-benzothiazol-2-ylmethyl-2-[4-(2-fluoro-ethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide (184043-78-5)

Guidance literature:

Multi-step reaction with 4 steps

1: imidazole

2: SO₃; pyridine / Heating

3: POCl₃; pyridine / acetonitrile / 20 °C / microwave irradiation

4: DIPEA / CH₂Cl₂

With pyridine; 1H-imidazole; sulfur trioxide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; acetonitrile; 1: silylation / 2: sulphonation / 3: Chlorination / 4: sulfonylation;

DOI:10.1016/S0960-894X(00)00283-3

upstream raw materials:

2,2-dimethyl-malonyl monochloride

2,2-dimethylmalonic acid

2-(3,3-dimethyl-1,2,3,4-tetrahydro-quinolin-6-yl)-ethanol

(3,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinolin-6-yl)-acetic acid ethyl ester

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