(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-pentanedioic acid 1-allyl ester 5-[bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl] ester

Base Information

• Chemical Name: (S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-pentanedioic acid 1-allyl ester 5-[bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl] ester
• CAS No.: 241824-04-4
• Molecular Formula: C₃₅H₃₃F₇N₂O₇
• Molecular Weight: 726.645
• Mol file: 241824-04-4.mol

Synonyms:

Chemical Property of (S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-pentanedioic acid 1-allyl ester 5-[bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-pentanedioic acid 1-allyl ester 5-[bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl] ester

There total 7 articles about (S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-pentanedioic acid 1-allyl ester 5-[bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

L-N-Boc-Ala (15761-38-3) + (S)-2-Amino-pentanedioic acid 1-allyl ester 5-[bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl] ester → (S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-pentanedioic acid 1-allyl ester 5-[bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl] ester (241824-04-4)

Guidance literature:

With coupling reagent;

Reference yield:

bromopentafluorobenzene (344-04-7) → (S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-pentanedioic acid 1-allyl ester 5-[bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl] ester (241824-04-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Mg / diethyl ether

1.2: 94 percent / diethyl ether / 3 h / Heating

2.1: 100 percent / SOCl₂ / 0.17 h / 20 °C

3.1: 84 percent / DIPEA / CH₂Cl₂ / 14 h / 20 °C

4.1: morpholie / dimethylformamide

5.1: 52 percent / coupling reagent

With morpholine; thionyl chloride; coupling reagent; magnesium; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Substitution / 3.1: Alkylation / 4.1: Deacylation / 5.1: Acylation;

Reference yield:

4,4'-Difluorobenzophenone (345-92-6) → (S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-pentanedioic acid 1-allyl ester 5-[bis-(4-fluoro-phenyl)-pentafluorophenyl-methyl] ester (241824-04-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Mg / diethyl ether

1.2: 94 percent / diethyl ether / 3 h / Heating

2.1: 100 percent / SOCl₂ / 0.17 h / 20 °C

3.1: 84 percent / DIPEA / CH₂Cl₂ / 14 h / 20 °C

4.1: morpholie / dimethylformamide

5.1: 52 percent / coupling reagent

With morpholine; thionyl chloride; coupling reagent; magnesium; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Substitution / 3.1: Alkylation / 4.1: Deacylation / 5.1: Acylation;

upstream raw materials:

L-N-Boc-Ala

bromopentafluorobenzene

4,4'-Difluorobenzophenone

Nα-(9-fluorenylmethoxycarbonyl)-L-glutamic acid α-allyl ester