1-<2-methoxy>ethyl>-3-piperidinecarboxylic acid

Base Information

Chemical Name:1-<2-methoxy>ethyl>-3-piperidinecarboxylic acid
CAS No.:143747-42-6
Molecular Formula:C₂₃H₂₃F₆NO₅
Molecular Weight:507.43
Hs Code.:

1-<2-<bis<4-(trifluoromethoxy)phenyl>methoxy>ethyl>-3-piperidinecarboxylic acid

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Chemical Property of 1-<2-methoxy>ethyl>-3-piperidinecarboxylic acid

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Technology Process of 1-<2-methoxy>ethyl>-3-piperidinecarboxylic acid

There total 6 articles about 1-<2-methoxy>ethyl>-3-piperidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-{2-[Bis-(4-trifluoromethoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester

: 143747-42-6
1-<2-methoxy>ethyl>-3-piperidinecarboxylic acid

Guidance literature:: With lithium hydroxide; In methanol; for 64h; Ambient temperature;
DOI:10.1021/jm00100a032

Reference yield:

: 106-41-2
4-bromo-phenol

: 143747-42-6
1-<2-methoxy>ethyl>-3-piperidinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) SF₄ / 1.) a) 100 deg C, 1 h, b) 140 deg C, 2 h, 2.) 140 deg C, 4 h

2: 1.) Mg / 2.) THF, reflux, 4 h

3: conc. H₂SO₄ / toluene / 2 h / 85 - 90 °C

4: K₂CO₃ / acetonitrile / 15 h / Heating

5: 2 N aq. LiOH / methanol / 64 h / Ambient temperature

With lithium hydroxide; sulfuric acid; sulfur tetrafluoride; potassium carbonate; magnesium; In methanol; toluene; acetonitrile;
DOI:10.1021/jm00100a032

Reference yield:

: 407-14-7
1-bromo-4-(trifluoromethoxy)benzene

: 143747-42-6
1-<2-methoxy>ethyl>-3-piperidinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg / 2.) THF, reflux, 4 h

2: conc. H₂SO₄ / toluene / 2 h / 85 - 90 °C

3: K₂CO₃ / acetonitrile / 15 h / Heating

4: 2 N aq. LiOH / methanol / 64 h / Ambient temperature

With lithium hydroxide; sulfuric acid; potassium carbonate; magnesium; In methanol; toluene; acetonitrile;
DOI:10.1021/jm00100a032