Technology Process of 6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-aMine
There total 3 articles about 6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-aMine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridoxal phosphate; transaminase from Aspergillus terreus (XP_001209325.1); isopropylamine hydrochloride;
In
aq. phosphate buffer; dimethyl sulfoxide;
at 40 ℃;
for 18h;
pH=7.5;
Large scale;
Enzymatic reaction;
DOI:10.1021/acs.oprd.7b00096
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridoxal phosphate; isopropylamine; aminotransaminase-47 / aq. phosphate buffer / 72 h / 37 - 39 °C / pH 7.3 / Large scale; Enzymatic reaction
2: sodium hydroxide / tert-butyl methyl ether; water / pH 10.8 - 11.2 / Large scale
With
pyridoxal phosphate; aminotransaminase-47; isopropylamine; sodium hydroxide;
In
aq. phosphate buffer; tert-butyl methyl ether; water;
DOI:10.1021/acs.oprd.7b00096
- Guidance literature:
-
With
sodium hydroxide;
In
tert-butyl methyl ether; water;
pH=10.8 - 11.2;
Large scale;
DOI:10.1021/acs.oprd.7b00096
