2,3,3a,4,5,9b-hexahydro-4-oxo-5-(phenylsulfonyl)benzindene

Base Information

Chemical Name:2,3,3a,4,5,9b-hexahydro-4-oxo-5-(phenylsulfonyl)benzindene
CAS No.:113812-01-4
Molecular Formula:C₁₉H₁₈O₃S
Molecular Weight:326.416
Hs Code.:

2,3,3a,4,5,9b-hexahydro-4-oxo-5-(phenylsulfonyl)benz<e>indene

Synonyms:

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Chemical Property of 2,3,3a,4,5,9b-hexahydro-4-oxo-5-(phenylsulfonyl)benzindene

Chemical Property:

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Technology Process of 2,3,3a,4,5,9b-hexahydro-4-oxo-5-(phenylsulfonyl)benzindene

There total 10 articles about 2,3,3a,4,5,9b-hexahydro-4-oxo-5-(phenylsulfonyl)benzindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113812-00-3
2-[4-(2-Benzenesulfonylmethyl-phenyl)-4-bromo-butyl]-malonic acid dimethyl ester

: 113812-01-4
2,3,3a,4,5,9b-hexahydro-4-oxo-5-(phenylsulfonyl)benzindene

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; for 1h; Yield given; Ambient temperature;
DOI:10.1021/jo00244a015

Reference yield:

: 111170-32-2
1-(3-hydroxy-1-propyl)-2-<(phenylsulfonyl)methyl>benzene

: 113812-01-4
2,3,3a,4,5,9b-hexahydro-4-oxo-5-(phenylsulfonyl)benzindene

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / CH₂Cl₂ / 3 h / 0 °C

2: 77 percent / dimethylformamide / 60 °C

3: 1.) 1 M Dibal 2.) 5percent aq. HCl / 1.) CH₂Cl₂, hexane, 0 deg C, 1 h, 2.) 30 min

4: LiAlH₄ / tetrahydrofuran / 30 h / 0 °C

5: triethylamine / CH₂Cl₂ / 3 h / 0 °C

6: NaI / acetone / 2 h / Heating

7: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, THF, 50 deg C, 5 h

8: 100 percent / NBS, benzoyl peroxide / CCl₄ / 0.25 h / Heating; Irradiation

9: tert-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / Ambient temperature

With hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; Perbenzoic acid; potassium tert-butylate; sodium hydride; diisobutylaluminium hydride; triethylamine; sodium iodide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/jo00244a015

Reference yield:

: 88116-02-3
1-bromomethyl-2-[(phenylsulfonyl)methyl]benzene

: 113812-01-4
2,3,3a,4,5,9b-hexahydro-4-oxo-5-(phenylsulfonyl)benzindene

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) NaCl, 2.) LiAlH₄ / 1.) DMSO, H₂O, 160-170 deg C, 4 h, 2.) THF, 0 deg C

2: triethylamine / CH₂Cl₂ / 3 h / 0 °C

3: 77 percent / dimethylformamide / 60 °C

4: 1.) 1 M Dibal 2.) 5percent aq. HCl / 1.) CH₂Cl₂, hexane, 0 deg C, 1 h, 2.) 30 min

5: LiAlH₄ / tetrahydrofuran / 30 h / 0 °C

6: triethylamine / CH₂Cl₂ / 3 h / 0 °C

7: NaI / acetone / 2 h / Heating

8: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, THF, 50 deg C, 5 h

9: 100 percent / NBS, benzoyl peroxide / CCl₄ / 0.25 h / Heating; Irradiation

10: tert-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 1 h / Ambient temperature

With hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; Perbenzoic acid; potassium tert-butylate; sodium hydride; diisobutylaluminium hydride; triethylamine; sodium iodide; sodium chloride; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/jo00244a015