[(1S)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: [(1S)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
• CAS No.: 137102-30-8
• Molecular Formula: C13H20N2O2
• Molecular Weight: 236.314
• Hs Code.: 2924297099
• Mol file: 137102-30-8.mol

Synonyms:tert-butyl N-[(1S)-2-amino-1-phenylethyl]carbamate;

Chemical Property of [(1S)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• PSA: 67.84000
• LogP: 3.11580
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl(2-amino-1-phenylethyl)carbamate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(1S)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

There total 25 articles about [(1S)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-(+)-1-<(butoxycarbonyl)amino>-1-phenylethyl azide (137102-29-5) → (S)-N1-tert-butoxycarbonyl-1-phenyl-1,2-ethanediamine (137102-30-8,142910-85-8)

Guidance literature:

(S)-(+)-1-<(butoxycarbonyl)amino>-1-phenylethyl azide; With triphenylphosphine; In tetrahydrofuran; for 8h; Reflux;

With water; In tetrahydrofuran; for 16h; Reflux;

DOI:10.1039/c2ob25693b

Reference yield: 91.0%

tert-butyl (1S)-2-nitro-1-phenylethylcarbamate → (S)-N1-tert-butoxycarbonyl-1-phenyl-1,2-ethanediamine (137102-30-8,142910-85-8)

Guidance literature:

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 ℃; for 0.25h;

DOI:10.1021/ol203170x

Reference yield: 87.0%

[(1S)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-phenylethyl]carbamic acid 1,1-dimethylethyl ester (1242073-15-9) → (S)-N1-tert-butoxycarbonyl-1-phenyl-1,2-ethanediamine (137102-30-8,142910-85-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux;

DOI:10.1002/adsc.201000111

upstream raw materials:

(S)-(+)-1-<(butoxycarbonyl)amino>-1-phenylethyl azide

{(S)-2-[2-((S)-1-Hydroxy-2,2-dimethyl-propyl)-4-oxo-4H-quinazolin-3-ylamino]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

3-((R)-2-Chloro-2-phenyl-ethylamino)-2-((S)-1-hydroxy-2,2-dimethyl-propyl)-3H-quinazolin-4-one

3-((S)-2-Azido-2-phenyl-ethylamino)-2-((S)-1-hydroxy-2,2-dimethyl-propyl)-3H-quinazolin-4-one

Downstream raw materials:

[(1S)-2-[[(4-methylphenyl)sulfonyl]amino]-1-phenylethyl]carbamic acid 1,1-dimethylethyl ester

(S)-tert-butyl 2-formamido-1-phenylethylcarbamate

(S)-(2-acetylamino-1-phenylethyl)carbamic acid tert-butyl ester

(S)-(9H-fluoren-9-yl)methyl 2-[(S)-2-(tert-butoxycarbonylamino)-2-phenylethylcarbamoyl]pyrrolidine-1-carboxylate

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