Phe-Met-NH_.C₆H₁₃(n)*HCOOH

Base Information

• Chemical Name: Phe-Met-NH_.C₆H₁₃(n)*HCOOH
• CAS No.: 96012-36-1
• Molecular Formula: CH₂O₂*C₂₀H₃₃N₃O₂S
• Molecular Weight: 425.593
• Mol file: 96012-36-1.mol

Synonyms:

Chemical Property of Phe-Met-NH_.C₆H₁₃(n)*HCOOH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phe-Met-NH_.C₆H₁₃(n)*HCOOH

There total 4 articles about Phe-Met-NH_.C₆H₁₃(n)*HCOOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Boc-Phe-Met-NHC6H13(n) (96012-51-0) → Phe-Met-NH.C6H13(n)*HCOOH (96012-36-1)

Guidance literature:

With ethandithiol; formic acid; for 4h; Ambient temperature;

Reference yield:

Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine (40290-63-9) → Phe-Met-NH.C6H13(n)*HCOOH (96012-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / 2N NaOH / dioxane; H₂O / 1 h / Ambient temperature

2: 1) N-methylmorpholine, isobutyl chloroformate / 1) THF, -15 deg C, 20 min, 2a) -15 deg C, 1 h, b) r.t., 2 h

3: 80 percent / 98percent HCOOH, ethanedithiol / 4 h / Ambient temperature

With 4-methyl-morpholine; ethandithiol; sodium hydroxide; formic acid; isobutyl chloroformate; In 1,4-dioxane; water;

Reference yield:

hexan-1-amine (111-26-2) → Phe-Met-NH.C6H13(n)*HCOOH (96012-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) N-methylmorpholine, isobutyl chloroformate / 1) THF, -15 deg C, 20 min, 2a) -15 deg C, 1 h, b) r.t., 2 h

2: 80 percent / 98percent HCOOH, ethanedithiol / 4 h / Ambient temperature

With 4-methyl-morpholine; ethandithiol; formic acid; isobutyl chloroformate;

upstream raw materials:

Boc-Phe-Met-NHC₆H₁₃(n)

hexan-1-amine

Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine

boc-Phe-Met-OH

Downstream raw materials:

Boc-Tyr-D-Ala-Gly-Phe-Met-NHC₆H₁₃(n)