2r-methyl-4c-phenylcyclohexane-1t-carboxylic acid

Base Information

• Chemical Name: 2r-methyl-4c-phenylcyclohexane-1t-carboxylic acid
• CAS No.: 136661-73-9
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.296
• Mol file: 136661-73-9.mol

Synonyms:

Chemical Property of 2r-methyl-4c-phenylcyclohexane-1t-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2r-methyl-4c-phenylcyclohexane-1t-carboxylic acid

There total 8 articles about 2r-methyl-4c-phenylcyclohexane-1t-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1-((1R,2R,4R)-2-Methyl-4-phenyl-cyclohexyl)-ethanone → 2r-methyl-4c-phenylcyclohexane-1t-carboxylic acid (49708-71-6,49708-72-7,136661-73-9)

Guidance literature:

With sodium hypobromide; In 1,4-dioxane; 1.) RT, 2 h, 2.) 45-50 deg C, 1 h;

Reference yield:

rac-(1S,2R)-ethyl 2-methyl-4-oxocyclohexanecarboxylate (49617-26-7,62617-91-8,110559-81-4) → 2r-methyl-4c-phenylcyclohexane-1t-carboxylic acid (49708-71-6,49708-72-7,136661-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / methanol

With potassium hydroxide; In methanol;

DOI:10.1021/jm00265a015

Reference yield:

1-methylcyclohex-1-ene (591-49-1) → 2r-methyl-4c-phenylcyclohexane-1t-carboxylic acid (49708-71-6,49708-72-7,136661-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃ / CH₂Cl₂ / 5 h / Ambient temperature

2: 1.) diethylaniline, 2.) AlCl₃ / 1.) 180 deg C, 3 h, 2.) a) RT, 1 h, 2.) b) 60 deg C, 2 h

3: 30 percent / aq. sodium hypobromite / dioxane / 1.) RT, 2 h, 2.) 45-50 deg C, 1 h

With aluminium trichloride; sodium hypobromide; N,N-diethylaniline; In 1,4-dioxane; dichloromethane;

upstream raw materials:

(2-methyl-4-phenyl-cyclohexyl)-acetic acid

(2-methyl-cyclohex-1-enyl)-acetic acid ethyl ester

(+/-)-cis-2-methyl-4-oxocyclohexane-carboxylic acid

1-methylcyclohex-1-ene