2-[2-chloro-3-[2-(1,3-dihydro-1-octyl-3,3-dimethyl-2H-indolidine)ethyl-1-cyclohexyl]ethyl-5-(4-diethylamino)benzene]-1-octyl-3,3-dimethylindoline iodide

Base Information

• Chemical Name: 2-[2-chloro-3-[2-(1,3-dihydro-1-octyl-3,3-dimethyl-2H-indolidine)ethyl-1-cyclohexyl]ethyl-5-(4-diethylamino)benzene]-1-octyl-3,3-dimethylindoline iodide
• CAS No.: 1269802-74-5
• Molecular Formula: C₅₆H₇₇ClN₃*I
• Molecular Weight: 954.605
• Mol file: 1269802-74-5.mol

Synonyms:

Chemical Property of 2-[2-chloro-3-[2-(1,3-dihydro-1-octyl-3,3-dimethyl-2H-indolidine)ethyl-1-cyclohexyl]ethyl-5-(4-diethylamino)benzene]-1-octyl-3,3-dimethylindoline iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-chloro-3-[2-(1,3-dihydro-1-octyl-3,3-dimethyl-2H-indolidine)ethyl-1-cyclohexyl]ethyl-5-(4-diethylamino)benzene]-1-octyl-3,3-dimethylindoline iodide

There total 6 articles about 2-[2-chloro-3-[2-(1,3-dihydro-1-octyl-3,3-dimethyl-2H-indolidine)ethyl-1-cyclohexyl]ethyl-5-(4-diethylamino)benzene]-1-octyl-3,3-dimethylindoline iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1-formyl-2-chloro-3-hydroxymethylene-5-(4-diethylaminophenyl)cyclohexene (1269802-53-0) + 1-octyl-2,3,3-trimethyl-3H-indol-1-ium iodide (96359-59-0) → 2-[2-chloro-3-[2-(1,3-dihydro-1-octyl-3,3-dimethyl-2H-indolidine)ethyl-1-cyclohexyl]ethyl-5-(4-diethylamino)benzene]-1-octyl-3,3-dimethylindoline iodide (1269802-74-5)

Guidance literature:

In butan-1-ol; benzene; for 4h; Reflux;

Reference yield:

4-(4-nitrophenyl)cyclohexan-1-one (124500-60-3) → 2-[2-chloro-3-[2-(1,3-dihydro-1-octyl-3,3-dimethyl-2H-indolidine)ethyl-1-cyclohexyl]ethyl-5-(4-diethylamino)benzene]-1-octyl-3,3-dimethylindoline iodide (1269802-74-5)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / isopropyl alcohol / 7 h / 50 °C

2: sodium carbonate / isopropyl alcohol / 6 h / Reflux

3: trichlorophosphate / dichloromethane / 5 h / 0 - 5 °C / Reflux

4: butan-1-ol; benzene / 4 h / Reflux

With palladium 10% on activated carbon; hydrogen; sodium carbonate; trichlorophosphate; In dichloromethane; isopropyl alcohol; butan-1-ol; benzene;

Reference yield:

1-phenyl-4-cyclohexanone (4894-75-1) → 2-[2-chloro-3-[2-(1,3-dihydro-1-octyl-3,3-dimethyl-2H-indolidine)ethyl-1-cyclohexyl]ethyl-5-(4-diethylamino)benzene]-1-octyl-3,3-dimethylindoline iodide (1269802-74-5)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / 7 h / 0 - 5 °C

2: palladium 10% on activated carbon; hydrogen / isopropyl alcohol / 7 h / 50 °C

3: sodium carbonate / isopropyl alcohol / 6 h / Reflux

4: trichlorophosphate / dichloromethane / 5 h / 0 - 5 °C / Reflux

5: butan-1-ol; benzene / 4 h / Reflux

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; sodium carbonate; trichlorophosphate; In dichloromethane; isopropyl alcohol; butan-1-ol; benzene;

upstream raw materials:

2,3,3-trimethylindoleniune

1-Iodooctane

4-(4-nitrophenyl)cyclohexan-1-one

4-(4-aminophenyl)-cyclohexanone

Refernces