Technology Process of (2R,4S,5R)-2-[1-(2-[1,3]Dioxan-2-yl-4,6-dimethoxy-phenyl)-4,5-dimethoxy-naphthalen-2-ylmethoxy]-3,5-dimethyl-4-phenyl-[1,3,2]oxazaphospholidine 2-sulfide
There total 13 articles about (2R,4S,5R)-2-[1-(2-[1,3]Dioxan-2-yl-4,6-dimethoxy-phenyl)-4,5-dimethoxy-naphthalen-2-ylmethoxy]-3,5-dimethyl-4-phenyl-[1,3,2]oxazaphospholidine 2-sulfide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / toluene-p-sulphonic acid / benzene / 2 h / Heating
2: 1.) Mg / 1.) THF, 2.) reflux, 5h
3: 1.) iodomethane, 2.) potassium hydroxide / 1.) nitromethane, 60 deg C, 2.) dimethyl sulphoxide, water, 100 deg C
4: K2CO3 / dimethylformamide / Ambient temperature
5: 77 percent / lithium aluminium hydride / tetrahydrofuran / Ambient temperature
6: 1.) NaH / 1.) THF, 60 deg C, 1h, 2.) reflux, 12h
With
potassium hydroxide; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; magnesium; methyl iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1039/P19910000845
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / potassium hydroxide / 2-methyl-propan-2-ol / 1.5 h / Heating
2: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, r.t., 24h, 2.) reflux, 48h
3: 1.) Mg / 1.) THF, 2.) reflux, 5h
4: 1.) iodomethane, 2.) potassium hydroxide / 1.) nitromethane, 60 deg C, 2.) dimethyl sulphoxide, water, 100 deg C
5: K2CO3 / dimethylformamide / Ambient temperature
6: 77 percent / lithium aluminium hydride / tetrahydrofuran / Ambient temperature
7: 1.) NaH / 1.) THF, 60 deg C, 1h, 2.) reflux, 12h
With
potassium hydroxide; lithium aluminium tetrahydride; triethyloxonium fluoroborate; sodium hydride; potassium carbonate; magnesium; methyl iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/P19910000845
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, r.t., 24h, 2.) reflux, 48h
2: 1.) Mg / 1.) THF, 2.) reflux, 5h
3: 1.) iodomethane, 2.) potassium hydroxide / 1.) nitromethane, 60 deg C, 2.) dimethyl sulphoxide, water, 100 deg C
4: K2CO3 / dimethylformamide / Ambient temperature
5: 77 percent / lithium aluminium hydride / tetrahydrofuran / Ambient temperature
6: 1.) NaH / 1.) THF, 60 deg C, 1h, 2.) reflux, 12h
With
potassium hydroxide; lithium aluminium tetrahydride; triethyloxonium fluoroborate; sodium hydride; potassium carbonate; magnesium; methyl iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/P19910000845
